Biermann C, Løken A, Riise R
Smestad Legesenter, Oslo, Norway.
J Antimicrob Chemother. 1988 Jul;22 Suppl B:155-8. doi: 10.1093/jac/22.supplement_b.155.
A total of 221 patients from 21 general practitioners was entered in a double-blind comparative study of spiramycin and doxycycline in the treatment of pneumonia and acute exacerbations of chronic bronchitis. One-hundred-and-five patients were randomized to treatment with spiramycin tablets for 5 1/2 days and 116 patients were randomized to treatment with doxycycline tablets for nine days. The efficacy and side effects of the two treatment regimens were observed. Of the 221 patients included, 191 were acceptable for evaluation, 91 in the spiramycin group and 100 in the doxycycline group. Three patients in the spiramycin group withdrew because of lack of efficacy and one patient in the doxycycline group withdrew because of side effects (feeling unwell and blurred vision). No significant differences in efficacy or safety were found between the two treatments.
来自21位全科医生的221名患者参与了一项螺旋霉素和强力霉素治疗肺炎及慢性支气管炎急性加重期的双盲对照研究。105名患者被随机分配接受螺旋霉素片治疗5.5天，116名患者被随机分配接受强力霉素片治疗9天。观察了两种治疗方案的疗效和副作用。在纳入的221名患者中，191名可接受评估，螺旋霉素组91名，强力霉素组100名。螺旋霉素组有3名患者因疗效不佳退出，强力霉素组有1名患者因副作用（感觉不适和视力模糊）退出。两种治疗在疗效或安全性上未发现显著差异。
