Samarut C, Gebuhrer L, Brochier J, Betuel H, Revillard J P
Eur J Immunol. 1977 Dec;7(12):908-10. doi: 10.1002/eji.1830071217.
Human peripheral blood T cells bearing receptors for the Fc portion of immunoglobulins were characterized by the formation of double rosettes with sheep red blood cells and IgG-coated chicken erythrocytes (EA). Treatment of cells by anti-"Ia-like" antisera inhibits the binding of EA. Inihbition appeared to be specific since anti-HLA-A and HLA-B antibodies did not inhibit the formation of EA rosettes, whereas F (ab')2 fragments of anti-Ia-like IgG were found to be as potent inhibitors as the whole IgG. This result shows that in human and in mice, Ia-like determinants arepresent, close to Fc gamma receptors, on the surface of the T lymphocytes bearing such receptors.
带有免疫球蛋白Fc段受体的人外周血T细胞的特征是能与绵羊红细胞和IgG包被的鸡红细胞（EA）形成双玫瑰花结。用抗“类Ia”抗血清处理细胞可抑制EA的结合。这种抑制似乎具有特异性，因为抗HLA - A和HLA - B抗体并不抑制EA玫瑰花结的形成，而抗类Ia IgG的F（ab'）2片段被发现与完整的IgG一样是有效的抑制剂。这一结果表明，在人和小鼠中，在带有此类受体的T淋巴细胞表面，靠近Fcγ受体处存在类Ia决定簇。
