Segev S, Samra Z, Eliav E, Rosen N, Rubinstein E
Infectious Diseases Unit, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
J Antimicrob Chemother. 1988 Jul;22 Suppl B:183-7. doi: 10.1093/jac/22.supplement_b.183.
Twenty-five male patients with nongonococcal urethritis including 15 chlamydial infections, were treated with spiramycin for ten days. All but four patients had been treated previously, mostly with tetracyclines. Chlamydia trachomatis was cultured in seven patients and was detected in three additional men by immunofluorescent smear. Five other patients had antibodies to chlamydia, and one patient yielded a positive culture for Ureaplasma urealyticum and Mycoplasma hominis. A successful clinical response was observed in 64% of the patients; C. trachomatis was eradicated from six of seven patients with positive cultures and the three positive direct smears were negative after treatment. It is concluded that spiramycin can be used effectively for the therapy of acute nongonococcal urethritis, as well as in patients who have failed to respond to previous treatment with tetracyclines and erythromycin.
25名患有非淋菌性尿道炎的男性患者（其中15例为衣原体感染）接受了螺旋霉素治疗，疗程为10天。除4名患者外，其他患者此前大多接受过四环素治疗。7名患者培养出沙眼衣原体，另外3名男性通过免疫荧光涂片检测出沙眼衣原体。另有5名患者有衣原体抗体，1名患者解脲脲原体和人型支原体培养呈阳性。64%的患者临床反应良好；7例培养阳性患者中的6例沙眼衣原体被根除，3例直接涂片阳性患者治疗后转阴。结论是，螺旋霉素可有效用于治疗急性非淋菌性尿道炎，以及对先前四环素和红霉素治疗无反应的患者。
