Juvakoski T, Allgulander C, Lassus A
Sex Transm Dis. 1981 Jan-Mar;8(1):12-5. doi: 10.1097/00007435-198101000-00005.
Rosaramicin, a new macrolide antibiotic, is active in vitro against Chlamydia trachomatis and Ureaplasma urealyticum. Its efficacy in the treatment of uncomplicated nongonococcal urethritis was evaluated in 78 men. There were two parallel groups, one receiving rosaramicin and the other receiving tetracycline (dosage of either drug, 250 mg four times daily for seven days); all data were evaluated blindly. The follow-up period was six weeks. C. trachomatis was eliminated from all of 21 patients receiving rosaramicin and from 25 of 26 patients receiving tetracycline. C. trachomatis-negative patients responded clinically to both treatments. The results suggest that these two antibiotics yield similar clinical outcomes in the treatment of nongonococcal urethritis in adult men.
罗沙米星是一种新型大环内酯类抗生素，在体外对沙眼衣原体和解脲脲原体具有活性。对78名男性进行了评估，以确定其治疗单纯性非淋菌性尿道炎的疗效。分为两个平行组，一组接受罗沙米星治疗，另一组接受四环素治疗（两种药物的剂量均为每日4次，每次250mg，共7天）；所有数据均采用盲法评估。随访期为六周。接受罗沙米星治疗的21名患者和接受四环素治疗的26名患者中的25名患者的沙眼衣原体均被清除。沙眼衣原体阴性的患者对两种治疗均有临床反应。结果表明，这两种抗生素在治疗成年男性非淋菌性尿道炎方面产生相似的临床效果。
