Malinovsky Georgy, Yarmoshenko Ilia, Vasilyev Aleksey
Institute of Industrial Ecology UB RAS, 20, Sophy Kovalevskoy Str., Yekaterinburg, 620219, Russia.
Radiat Environ Biophys. 2019 Mar;58(1):39-47. doi: 10.1007/s00411-018-0770-5. Epub 2018 Dec 8.
Indoor exposure to natural radon is a factor that influences lung cancer risk worldwide. The present study includes a meta-analysis of epidemiological data on the relationship between lung cancer and indoor radon. Altogether, 31 case-control studies with 20,703 cases, 34,518 controls and 140 individual odds ratio (OR) estimates are included in the meta-analysis. Weighted median OR was calculated for five radon intervals. The following parameters were used for the weighting: standard error of OR, duration of radon concentration measurement, and relative number of controls in reference intervals. The dependence of the weighted median OR on the radon concentration was estimated applying linear non-threshold and threshold models. The results obtained suggest a significant linear no-threshold exposure-effect relationship for radon concentrations above 100 Bq/m, with a slope of 0.14 (95% confidence interval 0.08-0.21) per 100 Bq/m.
室内接触天然氡是影响全球肺癌风险的一个因素。本研究包括对肺癌与室内氡关系的流行病学数据进行荟萃分析。该荟萃分析共纳入31项病例对照研究，涉及20,703例病例、34,518例对照以及140个个体比值比（OR）估计值。针对五个氡浓度区间计算了加权中位数OR。加权时使用了以下参数：OR的标准误、氡浓度测量持续时间以及参考区间内对照的相对数量。应用线性无阈值模型和阈值模型估计加权中位数OR对氡浓度的依赖性。所得结果表明，对于氡浓度高于100 Bq/m³ 的情况，存在显著的线性无阈值暴露 - 效应关系，每100 Bq/m³ 的斜率为0.14（95%置信区间0.08 - 0.21）。
