Department of General Surgery, Beijing Friendship Hospital, Capital Medical University & National Clinical Research Center for Digestive Diseases, No. 95 Yong-an Road, Xi-Cheng District, Beijing, 100050, China.
Department of Nuclear Medicine, Beijing Friendship Hospital, Capital Medical University, No. 95 Yong-an Road, Xi-Cheng District, Beijing, 100050, China.
Obes Surg. 2019 Feb;29(2):617-625. doi: 10.1007/s11695-018-3571-7.
Laparoscopic sleeve gastrectomy (LSG) has become an increasingly popular metabolic surgical procedure. Alteration in motor gastric function is a fundamental feature following LSG but still remains controversial.
To determine the gastric emptying time 3 month after LSG, correlations between gastric emptying time and body weight, weight loss, and glycemia levels, alongside determining predictive factors of weight loss at the 3-month follow-up.
Twenty-one patients were recruited in this study. Gastric emptying time was measured using a standard solid-phase gastric emptying scan at both baseline and 3 months after LSG. Paired sample t tests and a general linear model with repeated measures were applied to investigate the alterations in major parameters after surgery. Univariate analyses were performed to evaluate the factors predicting weight loss at the 3-month follow-up.
Compared with baseline levels, gastric emptying time, body weight, and HbA levels decreased significantly at 3 months after LSG (P < 0.001). Significant positive correlations were detected between HbA levels and gastric emptying time at baseline (P = 0.03). Significant positive correlations were detected between HbA levels at baseline and change in gastric emptying time (P = 0.03). Univariate logistic regression revealed a lower baseline BMI level to be independently associated with %EWL (P < 0.001).
The rate of gastric emptying increased following LSG. Patients with a higher risk of type 2 diabetes at baseline had longer gastric emptying times prior to treatment and significantly shortened emptying times following surgery.
腹腔镜袖状胃切除术（LSG）已成为一种越来越受欢迎的代谢手术。LSG 后胃动力的改变是基本特征，但仍存在争议。
确定 LSG 后 3 个月的胃排空时间，胃排空时间与体重、体重减轻和血糖水平之间的相关性，以及确定 3 个月随访时体重减轻的预测因素。
本研究纳入了 21 名患者。胃排空时间在 LSG 前后均采用标准固相胃排空扫描进行测量。采用配对样本 t 检验和重复测量的一般线性模型来研究手术后主要参数的变化。采用单变量分析来评估 3 个月随访时体重减轻的预测因素。
与基线水平相比，LSG 后 3 个月胃排空时间、体重和 HbA 水平显著降低（P<0.001）。基线时 HbA 水平与胃排空时间呈显著正相关（P=0.03）。基线时 HbA 水平与胃排空时间变化呈显著正相关（P=0.03）。单变量逻辑回归显示，较低的基线 BMI 水平与 %EWL 独立相关（P<0.001）。
LSG 后胃排空率增加。基线时患 2 型糖尿病风险较高的患者在治疗前胃排空时间较长，术后排空时间显著缩短。
