Department of Pediatrics, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Eur Rev Med Pharmacol Sci. 2018 Nov;22(22):7858-7866. doi: 10.26355/eurrev_201811_16411.
To systematically review prednisone induced test results in the prognosis assessment of acute lymphoblastic leukemia in children.
Based on the established inclusion and exclusion criteria, studies of prednisone induced test in evaluating the prognosis of childhood acute lymphoblastic leukemia were electronically searched from January 1990 to November 2016 using Pubmed, Embase, The Cochrane Library, Web of Science, WanFang, VIP, and CNKI database. Two independent researchers browsed literature, extracted data and assessed the risk of bias of studies. Meta-analysis was performed using RevMen 5.3 software. A total of 17 articles were included.
Meta-analysis showed that after complete prednisone induced test in children, 5y-EFS, 8y-EFS adverse reactions, persistent remission and relapse were statistically significant differences between the prednisone good response (PGR) and prednisone poor response (PPR). There were statistical significance in T cell immune typing and the initial WBC of the two groups. Prognosis of prednisone good response group is better than prednisone poor response group.
The prednisone induction test is an important factor in predicting the prognosis of children with ALL.
系统评价泼尼松诱导试验在儿童急性淋巴细胞白血病预后评估中的作用。
根据既定的纳入和排除标准，从 1990 年 1 月至 2016 年 11 月，使用 Pubmed、Embase、The Cochrane Library、Web of Science、万方、VIP 和中国知网数据库，对评估儿童急性淋巴细胞白血病预后的泼尼松诱导试验进行电子检索。两名独立研究员浏览文献、提取数据并评估研究的偏倚风险。使用 RevMan 5.3 软件进行荟萃分析。共纳入 17 篇文章。
荟萃分析显示，在儿童完全接受泼尼松诱导试验后，PGR 组与 PPR 组在 5y-EFS、8y-EFS 不良事件、持续缓解和复发方面存在统计学差异。两组在 T 细胞免疫分型和初始白细胞计数方面存在统计学差异。PGR 组的预后优于 PPR 组。
泼尼松诱导试验是预测儿童 ALL 预后的重要因素。
