Diabetes Research Group, Swansea University, Medical School, Swansea, UK.
Applied Sport, Technology, Exercise and Medicine Research Centre (A-STEM), College of Engineering, Swansea University, Swansea, UK.
Diabet Med. 2019 Mar;36(3):349-358. doi: 10.1111/dme.13865. Epub 2018 Dec 7.
In the UK the National Institute of Health and Care Excellence (NICE) advocates intensive lifestyle programmes that attain the levels of daily physical activity set out by the Chief Medical Officer as a first-line strategy for improving the health of people at risk of developing diabetes or reducing the risk of development of Type 2 diabetes. For people with Type 2 diabetes, lifestyle measures complement pharmacological treatments that include both oral and injectable therapies. In line with this, NICE guidelines also support intensification of efforts to improve patient lifestyle along with these glucose-lowering therapies. There is a paucity of evidence, however, in the available published literature examining the association between glucose-lowering therapies and exercise metabolism. In the present review we explore the current knowledge with regard to the potential interactions of oral and non-insulin injectable therapies with physical activity in people at risk of, or who have, Type 2 diabetes, and present evidence that may inform healthcare professionals of the need to monitor patients more closely in their adaptation to both pharmacological therapy and physical activity.
在英国，国家卫生与保健卓越研究所（NICE）提倡实施密集的生活方式方案，以达到首席医疗官规定的日常身体活动水平，将其作为改善有发展为糖尿病风险人群健康或降低 2 型糖尿病发展风险的一线策略。对于 2 型糖尿病患者，生活方式措施是药物治疗的补充，其中包括口服和注射治疗。与此一致，NICE 指南还支持加强努力，改善患者的生活方式，同时进行这些降低血糖的治疗。然而，现有已发表文献中关于降糖治疗与运动代谢之间关联的证据很少。在本综述中，我们探讨了目前关于有发展为 2 型糖尿病风险或患有 2 型糖尿病的人群中，口服和非胰岛素注射治疗与体力活动之间潜在相互作用的相关知识，并提供了可能使医疗保健专业人员了解需要更密切监测患者对药物治疗和体力活动适应情况的证据。
