吲哚菁绿荧光成像在甲状腺手术中用于术中识别甲状旁腺的可行性。
Feasibility of indocyanine green fluorescence imaging for intraoperative identification of parathyroid glands during thyroid surgery.
作者信息
van den Bos Jacqueline, van Kooten Lottie, Engelen Sanne M E, Lubbers Tim, Stassen Laurents P S, Bouvy Nicole D
机构信息
Department of Surgery, Maastricht University Medical Center, Maastricht, The Netherlands.
Faculty of Health Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.
出版信息
Head Neck. 2019 Feb;41(2):340-348. doi: 10.1002/hed.25451. Epub 2018 Dec 11.
BACKGROUND
This study assessed the feasibility of near-infrared fluorescence imaging with indocyanine green (ICG) to identify the parathyroid glands (PGs) intraoperatively and to assess their perfusion after thyroid resection.
METHODS
Patients undergoing elective thyroidectomy were enrolled in this prospective study. An intravenous bolus of 7.5 mg ICG was administered twice: the first bolus to identify the PGs before resection of the thyroid and the second to assess vascularization of the PGs after resection.
RESULTS
A total of 30 operations in 26 patients were included. In 17 surgeries (56.7%), fluorescence imaging was of added value, especially to confirm the presence of a suspected PG. No intraoperative or postoperative complications occurred because of the use of ICG.
CONCLUSION
Near-infrared fluorescence imaging with the use of ICG for intraoperative identification of the PGs and the assessment of its vascularization is feasible and safe and can provide more certainty about the location of the PGs.
背景
本研究评估了使用吲哚菁绿（ICG）进行近红外荧光成像在术中识别甲状旁腺（PGs）以及评估甲状腺切除术后其灌注情况的可行性。
方法
接受择期甲状腺切除术的患者纳入本前瞻性研究。静脉推注7.5mg ICG两次：第一次推注在甲状腺切除术前识别PGs，第二次推注在切除术后评估PGs的血管化情况。
结果
共纳入26例患者的30台手术。在17例手术（56.7%）中，荧光成像具有附加价值，特别是用于确认可疑PG的存在。未因使用ICG而发生术中或术后并发症。
结论
使用ICG进行近红外荧光成像用于术中识别PGs及其血管化评估是可行且安全的，并且可以提供关于PGs位置的更多确定性。
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