Minowada J, Tsubota T, Nakazawa S, Srivastava B I, Huang C C, Oshimura M, Sonta S, Han T, Sinks L F, Sandberg A A
Haematol Blood Transfus. 1977;20:241-51. doi: 10.1007/978-3-642-66639-1_30.
Permanent human hematopoietic cell lines representing T-cell, B-cell and non T/non B (null-cell) leukemia have been established. Comparative analyses were made for their phenotype characteristics. A number of characteristics common within the 7 T-cell lines studied or distinct from other leukemia-type lines were described. Usefulness, validity and limitation of these findings are discussed in connection to the attempt at classification of ALL, CLL and blastic phase of CML. The great majority of CLL were SmIg+-B-cell leukemia and a single case of T-cell CLL was documented. Except 10% as T-cell ALL and a single case of B-cell ALL, the majority of ALL were found to be the non T/non B ALL. Nevertheless, little evidence was suggested from the present study in favor for a notion that the T-cell ALL and the non T/non B ALL are two distinct diseases.
已建立了代表T细胞、B细胞和非T/非B（空细胞）白血病的永久性人类造血细胞系。对它们的表型特征进行了比较分析。描述了在所研究的7个T细胞系中共同的一些特征，或与其他白血病类型细胞系不同的特征。结合对急性淋巴细胞白血病（ALL）、慢性淋巴细胞白血病（CLL）和慢性粒细胞白血病（CML）急变期进行分类的尝试，讨论了这些发现的实用性、有效性和局限性。绝大多数CLL是表面膜免疫球蛋白阳性（SmIg+）的B细胞白血病，记录了1例T细胞CLL。除了10%为T细胞ALL和1例B细胞ALL外，大多数ALL被发现是非T/非B ALL。然而，本研究几乎没有证据支持T细胞ALL和非T/非B ALL是两种不同疾病的观点。
