阿尔茨海默病的多靶点治疗策略
Multitarget therapeutic strategies for Alzheimer's disease.
作者信息
Ibrahim Mostafa M, Gabr Moustafa T
机构信息
Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt; Department of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA, USA.
Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt; Department of Chemistry, University of Iowa, Iowa City, IA, USA.
出版信息
Neural Regen Res. 2019 Mar;14(3):437-440. doi: 10.4103/1673-5374.245463.
Neurodegenerative diseases such as Alzheimer's, Huntington's and Parkinson's diseases have multifaceted nature because of the different factors contributing to their progression. The complex nature of neurodegenerative diseases has developed a pressing need to design multitarget-directed ligands to address the complementary pathways involved in these diseases. The major enzyme targets for development of therapeutics for Alzheimer's disease are cholinesterase and β-secretase enzymes. In this review, we discuss recent advances in profiling single target inhibitors based on these enzymes to multitarget-directed ligands as potential therapeutics for this devastating disease. In addition, therapeutics based on iron chelation strategy are discussed as well.
诸如阿尔茨海默病、亨廷顿病和帕金森病等神经退行性疾病具有多方面的特性，这是由促成其病情发展的不同因素所致。神经退行性疾病的复杂特性使得迫切需要设计多靶点导向配体，以应对这些疾病中涉及的互补途径。用于开发阿尔茨海默病治疗药物的主要酶靶点是胆碱酯酶和β-分泌酶。在本综述中，我们讨论了基于这些酶的单靶点抑制剂到多靶点导向配体作为这种毁灭性疾病潜在治疗药物的研究进展。此外，还讨论了基于铁螯合策略的治疗方法。
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