克雅氏病可能源自尸体硬脑膜移植。病例报告。

Creutzfeldt-Jakob disease probably acquired from a cadaveric dura mater graft. Case report.

作者信息

Thadani V, Penar P L, Partington J, Kalb R, Janssen R, Schonberger L B, Rabkin C S, Prichard J W

机构信息

Department of Neurology, Yale University School of Medicine, New Haven, Connecticut.

出版信息

J Neurosurg. 1988 Nov;69(5):766-9. doi: 10.3171/jns.1988.69.5.0766.

DOI:10.3171/jns.1988.69.5.0766

PMID:3054015

Abstract

A case of Creutzfeldt-Jakob disease (CJD) is reported in a 28-year-old woman who had received a cadaveric dural graft 19 months earlier after resection of a cholesteatoma. The circumstances of the case point to the graft as the most likely source of the disease. Cadaveric dura should be added to the list of materials that may transmit CJD, and it must be very carefully screened if it is used at all for grafting. Autologous tissue should be considered whenever possible.

摘要

报告了一例克雅氏病（CJD）病例，患者为一名28岁女性，她在19个月前因切除胆脂瘤接受了尸体硬脑膜移植。该病例情况表明移植物最有可能是疾病来源。尸体硬脑膜应被列入可能传播克雅氏病的材料清单，若用于移植，必须进行非常仔细的筛查。只要有可能，就应考虑使用自体组织。