Scop3D：蛋白质结构突变率的在线可视化。
Scop3D: Online Visualization of Mutation Rates on Protein Structure.
机构信息
VIB Bioinformatics Core , VIB , Ghent 120-9052 , Belgium.
VIB-UGent Center for Medical Biotechnology , VIB , Ghent 9000 , Belgium.
出版信息
J Proteome Res. 2019 Feb 1;18(2):765-769. doi: 10.1021/acs.jproteome.8b00681. Epub 2018 Dec 17.
Scop3D is a tool that automatically annotates protein structure with sequence conservation starting from a set of protein sequence variants. We present a complete upgrade and rewrite of Scop3D. We have included a DNA module that allows the analysis of single nucleotide polymorphisms in relation to the structural context of the protein. Scop3D therefore forms a bridge between genomics and protein structure. Moreover, Scop3D is now also available through an intuitive web-interface that makes the tool highly user-friendly.
Scop3D 是一个工具，它可以从一组蛋白质序列变体开始，自动注释蛋白质结构的序列保守性。我们对 Scop3D 进行了全面的升级和重写。我们还包含了一个 DNA 模块，该模块允许根据蛋白质的结构上下文分析单核苷酸多态性。因此，Scop3D 在基因组学和蛋白质结构之间架起了一座桥梁。此外，Scop3D 现在还可以通过直观的网络界面使用，使工具非常易于使用。
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