College of Science, State Key Laboratory of Agricultural Microbiology , Huazhong Agricultural University , Wuhan 430070 , China.
Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices , Soochow University Suzhou 215123 , China.
ACS Nano. 2019 Jan 22;13(1):284-294. doi: 10.1021/acsnano.8b05982. Epub 2018 Dec 17.
Multifunctional nanoplatforms with special advantages in the diagnosis and treatment of cancer have been widely explored in nanomedicine. Herein, we synthesize two-dimensional core-shell nanocomposites (TiC@Au) via a seed-growth method starting from the titanium carbide (TiC) nanosheets, a classical type of MXene nanostructure. After growing gold on the surface of TiC nanosheets, the stability and biocompatibility of the nanocomposites are greatly improved by the thiol modification. Also importantly, the optical absorption in the near-infrared region is enhanced. Utilizing the ability of the high optical absorbance and strong X-ray attenuation, the synthesized TiC@Au nanocomposites are used for photoacoustic and computed tomography dual-modal imaging. Importantly, the mild photothermal effect of the TiC@Au nanocomposites could improve the tumor oxygenation, which significantly enhances the radiotherapy. No obvious long-term toxicity of the nanocomposites is found at the injected dose. This work highlights the promise of special properties of MXene-based multifunctional nanostructures for cancer theranostics.
多功能纳米平台在癌症的诊断和治疗方面具有特殊优势，在纳米医学领域得到了广泛的探索。在此，我们通过种子生长法从碳化钛（TiC）纳米片（一种经典的 MXene 纳米结构）出发合成了二维核壳纳米复合材料（TiC@Au）。在 TiC 纳米片表面生长金后，通过巯基修饰大大提高了纳米复合材料的稳定性和生物相容性。同样重要的是，增强了近红外光的吸收。利用高吸光度和强 X 射线衰减的能力，合成的 TiC@Au 纳米复合材料用于光声和计算机断层扫描双模式成像。重要的是，TiC@Au 纳米复合材料温和的光热效应可以改善肿瘤的氧合作用，从而显著增强放射治疗。在注射剂量下，纳米复合材料没有明显的长期毒性。这项工作突出了基于 MXene 的多功能纳米结构在癌症治疗中的特殊性质的应用前景。
