CRISPR 敲除“房间里的大象”。
CRISPRing the Elephant in the Room.
机构信息
Molecular Infection Medicine Sweden (MIMS), Department of Molecular Biology, Umeå University, Umeå, SE-901 87, Sweden.
出版信息
Cell Host Microbe. 2018 Dec 12;24(6):754-755. doi: 10.1016/j.chom.2018.11.015.
PMID:30543773
Abstract
The importance of guanylyl-cyclases (GCs) in apicomplexa has remained elusive due to the large size of the genes. Two recent studies, including Brown and Sibley, 2018 in this issue of Cell Host & Microbe, make elegant use of genome editing with CRISPR-Cas9 to characterize roles of GCs in Toxoplasma and Plasmodium.
摘要
由于基因较大，黏着斑激酶（GCs）在顶复门生物中的重要性仍然难以捉摸。包括布朗和西布利（Brown and Sibley）在内的两项最近的研究，在本期《细胞宿主与微生物》中，巧妙地利用 CRISPR-Cas9 基因组编辑来描述 GCs 在弓形虫和疟原虫中的作用。
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