Department of Urology, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, Jingzhou, China.
Department of Urology, Renmin Hospital of Wuhan University, Wuhan, China,
Med Princ Pract. 2019;28(2):124-132. doi: 10.1159/000496206. Epub 2018 Dec 13.
Prostate cancer (PCa) is one of the most prevalent types of cancer among men worldwide. The incidence of PCa is increasing in China. Therefore, there is an urgent need to identify novel diagnostic and prognostic markers for PCa to improve the treatment of the disease.
The Cancer Genome Atlas (TCGA) and GEO database were used to analyze the expression of miR-192, and the relationship between miR-192 and the clinical features of patients with PCa. Cell cycle and cell proliferation assay were used to detect the functional roles of miR-192 in PCa. Bioinformatic analysis for miR-192-5p was performed using gene ontology and KEGG analysis.
By analyzing the dataset of TCGA, we found that miR-192 was overexpressed in PCa samples compared to normal tissues and was upregulated in high-grade PCa compared to low-grade PCa. We also observed that higher miR-192 expression was associated with a shorter biochemical recurrence-free survival time. Our results also demonstrated that miR-192 promoted PCa cell proliferation and cell cycle progression.
These results suggest that miR-192 may be considered for use as a potential diagnostic and therapeutic target of PCa.
前列腺癌（PCa）是全球男性最常见的癌症类型之一。在中国，PCa 的发病率正在上升。因此，迫切需要鉴定用于 PCa 的新型诊断和预后标志物，以改善疾病的治疗。
使用癌症基因组图谱（TCGA）和 GEO 数据库分析 miR-192 的表达，并分析 miR-192 与 PCa 患者临床特征之间的关系。通过细胞周期和细胞增殖测定检测 miR-192 在 PCa 中的功能作用。通过基因本体论和 KEGG 分析进行 miR-192-5p 的生物信息学分析。
通过分析 TCGA 数据集，我们发现与正常组织相比，miR-192 在 PCa 样本中表达上调，与低级别 PCa 相比，高级别 PCa 中 miR-192 表达上调。我们还观察到较高的 miR-192 表达与生化无复发生存时间较短有关。我们的结果还表明，miR-192 促进了 PCa 细胞的增殖和细胞周期进程。
这些结果表明，miR-192 可被视为 PCa 的潜在诊断和治疗靶标。
