Thomas L L, Mertens M J, von dem Borne A E, van Boxtel C J, Veenhof C H, Veies E P
Department of Hematology, Academic Medical Center, Amsterdam, The Netherlands.
Med Toxicol Adverse Drug Exp. 1988 Jul-Aug;3(4):253-63. doi: 10.1007/BF03259938.
In this article the pharmacological management of accidental drug overdose is discussed, with various treatments for overdose proposed, as supported by clinical facts and speculation. Current knowledge is outlined concerning dacarbazine, nitrosourea compounds, melphalan, procarbazine, cyclophosphamide, VP-16.213, l-asparaginase (colaspase), 6-mercaptopurine, mustine (nitrogen mustard), intravenous or intrathecal methotrexate (amethopterin), cytarabine (cytosine arabinoside), fluorouracil and bleomycin.
本文讨论了意外药物过量的药物治疗方法，并根据临床事实和推测提出了各种过量用药的治疗方案。概述了关于达卡巴嗪、亚硝基脲类化合物、美法仑、丙卡巴肼、环磷酰胺、依托泊苷、左旋门冬酰胺酶（结肠酶）、6-巯基嘌呤、氮芥、静脉内或鞘内注射甲氨蝶呤（氨甲蝶呤）、阿糖胞苷（胞嘧啶阿拉伯糖苷）、氟尿嘧啶和博来霉素的现有知识。
