Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", 34137 Trieste, Italy.
Department of Medical, Surgery and Health Sciences, University of Trieste, 34137 Trieste, Italy.
Int J Mol Sci. 2018 Dec 12;19(12):4018. doi: 10.3390/ijms19124018.
Gynecologic cancers are an important cause of worldwide mortality. The interstitium consists of solid and fluid phases, situated between the blood vessels and cells. The interstitial fluid (IF), or fluid phase, is an extracellular fluid bathing and surrounding the tissue cells. The TIF (tumor interstitial fluid) is a dynamic fluid rich in lipids, proteins and enzyme-derived substances. The molecules found in the IF may be associated with pathological changes in tissues leading to cancer growth and metastatization. Proteomic techniques have allowed an extensive study of the composition of the TIF as a source of biomarkers for gynecologic cancers. In our review, we analyze the composition of the TIF, its formation process, the sampling methods, the consequences of its accumulation and the proteomic analyses performed, that make TIF valuable for monitoring different types of cancers.
妇科癌症是全球死亡率的一个重要原因。间质由固相与液相组成，位于血管和细胞之间。间质液（IF）或液相是一种细胞外液，可浸润和包围组织细胞。肿瘤间质液（TIF）是一种富含脂质、蛋白质和酶衍生物质的动态液体。IF 中发现的分子可能与导致癌症生长和转移的组织病理变化有关。蛋白质组学技术使对 TIF 的组成进行广泛研究成为可能，TIF 是妇科癌症生物标志物的来源。在我们的综述中，我们分析了 TIF 的组成、形成过程、采样方法、其积累的后果以及进行的蛋白质组学分析，这些都使 TIF 成为监测不同类型癌症的有价值的工具。
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