Departamento de Química Orgánica, Facultad de Ciencias, and Instituto de Síntesis Orgánica (ISO), Uni-versidad de Alicante, Apdo. 99, 03080 Alicante, Spain.
Departamento de Química Orgánica I, Universidad del País Vasco, Apdo. 1072, 20080 San Sebastián, Spain.
Molecules. 2018 Dec 12;23(12):3299. doi: 10.3390/molecules23123299.
A primary amine-salicylamide derived from chiral -cyclohexane-1,2-diamine was used as an organocatalyst for the enantioselective conjugate addition of aldehydes, mainly α,α-disubstituted to -substituted maleimides. The reaction was performed in toluene as a solvent at room temperature. The corresponding enantioenriched adducts were obtained with high yields and enantioselectivities up to 94%. Theoretical calculations were used to justify the stereoinduction.
一种由手性 -环己烷-1,2-二胺衍生的伯胺-水杨酰胺被用作有机催化剂，用于醛的对映选择性共轭加成，主要是 α,α-二取代到 -取代马来酰亚胺。反应在甲苯溶剂中于室温下进行。相应的对映体富集加成产物以高产率和高达 94%的对映选择性获得。理论计算用于证明立体诱导。
