Phanuphak P, Schocket A, Kohler P F
Clin Allergy. 1978 Sep;8(5):429-33. doi: 10.1111/j.1365-2222.1978.tb01493.x.
Combined H1 (cyproheptadine) and H2 antihistamines (cimetidine) were tried in eight patients with chronic urticaria who were previously unresponsive to conventional anti-urticarial regimens, including type I antihistamines, hydroxyzine, ephedrine and corticosteroids. 50% of the patients responded with 90% or greater improvement within 10 days. The remaining 50% showed no benefit. Side effects of the medications were minimal. These results indicate that a 10 day trial of both H1 and H2 antihistamines may be useful in patients with chronic urticaria resistant to all other standard treatment modalities.
对8例慢性荨麻疹患者试用了联合H1（赛庚啶）和H2抗组胺药（西咪替丁），这些患者先前对包括I型抗组胺药、羟嗪、麻黄碱和皮质类固醇在内的传统抗荨麻疹治疗方案均无反应。50%的患者在10天内病情改善90%或更佳。其余50%的患者未见疗效。药物副作用极小。这些结果表明，对所有其他标准治疗方式均耐药的慢性荨麻疹患者，试用10天的H1和H2抗组胺药可能有效。
