Norn S, Permin H, Skov P S
Allergy. 1980 Jun;35(4):357-61. doi: 10.1111/j.1398-9995.1980.tb01778.x.
Experiments in the skin and synovialis have thrown new light on the allergic-inflammatory reactions. The inflammatory effect of histamine is thus due to stimulation of two different types of receptors in the vessels, i.e. histaminergic H1 and H2 receptors. Both types of receptors are of importance for the immediate cutaneous response to allergens and histamine. Treatment with a combination of H1 antagonists (classical antihistamines) and the H2 antagonist cimetidine will thus cause a much stronger inhibition of the urticarial reactions than treatment with the H1 and H2 antagonist alone. It is therefore probable that a combination therapy could have an advantage over the traditional treatment with classical antihistamines in urticaria and other histamine-mediated skin diseases. Histamine might also be of importance for the swelling of the joints in inflammatory diseases such as rheumatoid arthritis, and clinical trials with H1 and H2 antagonists are in progress.
在皮肤和滑膜组织上进行的实验为过敏性炎症反应带来了新的认识。组胺的炎症作用是由于刺激了血管中的两种不同类型的受体，即组胺能H1和H2受体。这两种类型的受体对于皮肤对过敏原和组胺的即时反应都很重要。因此，联合使用H1拮抗剂（传统抗组胺药）和H2拮抗剂西咪替丁进行治疗，比单独使用H1和H2拮抗剂能更有效地抑制荨麻疹反应。因此，在荨麻疹和其他组胺介导的皮肤病中，联合治疗可能比传统的抗组胺药治疗更具优势。组胺在类风湿性关节炎等炎症性疾病的关节肿胀中可能也起重要作用，目前正在进行H1和H2拮抗剂的临床试验。
