Baguley B C
Cancer Research Laboratory, University of Auckland School of Medicine.
N Z Med J. 1988 Oct 26;101(856 Pt 2):700-2.
Modern molecular and cellular biology provide many new techniques for the analysis of genes and proteins in normal and diseased cells. Most progress to date has occurred in cancer, infectious diseases and some areas of immunology because of the ability of the cells involved to proliferate. In colorectal cancer, genetic lesions may be detected now in at least three different chromosomal regions, and studies are underway to clarify the functions of the critical genes in each of these regions. Progress is now being made in other diseases such as Alzheimer's disease where cell proliferation is not a characteristic of the affected tissue. In general, large multidisciplinary teams, often with a substantial clinical input, are required for progress. New Zealand has a social structure which should facilitate the setting up of such groups, and in addition has a number of unique research problems worthy of study. It is important for funding bodies to realise the critical part which basic research has to play in approaching health problems, and to both plan and facilitate its development.
现代分子与细胞生物学为分析正常细胞和病变细胞中的基因与蛋白质提供了许多新技术。由于相关细胞具有增殖能力，迄今为止，在癌症、传染病及一些免疫学领域取得了最大进展。在结直肠癌中，现在至少能在三个不同的染色体区域检测到基因损伤，并且正在开展研究以阐明这些区域中关键基因的功能。在诸如阿尔茨海默病等其他疾病方面也正在取得进展，而细胞增殖并非受影响组织的特征。一般而言，取得进展需要大型多学科团队，通常还需要大量临床投入。新西兰拥有有利于组建此类团队的社会结构，此外还有一些值得研究的独特研究问题。对于资助机构来说，认识到基础研究在解决健康问题中必须发挥的关键作用，并规划和推动其发展非常重要。
