[接种量效应对5-硝基咪唑3种衍生物及其他11种抗生素对脆弱拟杆菌最低抑菌浓度的影响]
[Influence of the inoculum effect on minimal inhibitory concentrations of 3 derivatives of 5-nitro-imidazole and 11 other antibiotics on Bacteroides fragilis].
作者信息
Dusart G, Simeon de Buochberg M, Maillols H, Zuccarelli M, Attisso M A
机构信息
Laboratoire de Bactériologie et Biologie cellulaire, Factulé de Pharmacie, Montpellier.
出版信息
Pathol Biol (Paris). 1988 Jun;36(5 Pt 2):685-9.
Three nitro-imidazole derivatives and eleven other antibiotics were studied for both their antimicrobial activity and the degree to which they produced inoculum effect on twenty strains of Bacteroides fragilis group. Five inocula were studied ranging from 10(5) to 10(9) CFU/ml. Statistical analysis show the significant influence of inoculum and those of strains. Nitro-imidazole derivatives exhibited a large inoculum effect while other antibiotics exhibited only a minimal to-no-inoculum effect.
对三种硝基咪唑衍生物和其他十一种抗生素进行了研究，考察它们对二十株脆弱拟杆菌属细菌的抗菌活性以及产生接种物效应的程度。研究了五种接种物，浓度范围为10(5)至10(9) CFU/ml。统计分析表明接种物和菌株都有显著影响。硝基咪唑衍生物表现出较大的接种物效应，而其他抗生素仅表现出极小至无接种物效应。
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