Etesse-Carsenti H, Garraffo R, Giaume F, Barbarin A, Bernard E, Lapalus P, Argenson C, Drugeon H B, Dellamonica P
Laboratoire de Pharmacologie, Faculté de Médecine, Hôpital St-Roch.
Pathol Biol (Paris). 1988 Jun;36(5 Pt 2):715-8.
A better understanding of the pharmacokinetics of pefloxacin in human bone is warranted by the efficacy of this drug in the treatment of bone and joint infections. Surgical bone samples were taken at 30 mn, 1h, 6h, 12h and 24 h after the administration of a single 800 mg intravenous dose of pefloxacin over 1 hour for 26 patients who underwent surgery in an orthopedic surgery ward. Drug concentration was measured by a microbiological method (extraction of the antibiotic in buffer or with chloroform). Up until the 24th hour, in 25/26 cases, the bone levels were superior to 2 mg/l (the critical concentration of pefloxacin) in cortical as well as in spongy bone. Our study reveals a good diffusion of pefloxacin in bone, results which support the idea that this antibiotic may be prophylactically effective in orthopedic surgery.
鉴于培氟沙星在治疗骨与关节感染方面的疗效，有必要更好地了解其在人体骨骼中的药代动力学。在一个整形外科病房，对26例接受手术的患者在1小时内静脉注射单次800毫克培氟沙星后，于30分钟、1小时、6小时、12小时和24小时采集手术骨样本。通过微生物学方法（在缓冲液或氯仿中提取抗生素）测量药物浓度。直到第24小时，在25/26例病例中，皮质骨和松质骨中的骨浓度均高于2毫克/升（培氟沙星的临界浓度）。我们的研究表明培氟沙星在骨骼中具有良好的扩散性，这些结果支持了这种抗生素在整形外科手术中可能具有预防效果的观点。
