Dornbusch K
Scand J Infect Dis Suppl. 1976(9):47-53.
Measurements of antibacterial activity in bone from 25 patients undergoing orthopaedic surgery were performed after preoperative treatment with doxycycline in a single dose of 200 mg. The antibiotic was given by intravenous infusion during 30-40 minutes, and the operation was performed 2-6 hours after administration of the dose. Using the agar diffusion method, the concentrations ranged from 0.05-0.6 mug/g. Using the electrophoretic method, higher levels of doxycycline were found, possibly as a consequence of a diminution in the binding capacity of the bone.
对25例接受骨科手术的患者，在术前单次给予200mg强力霉素治疗后，对其骨组织中的抗菌活性进行了测量。抗生素通过静脉输注在30 - 40分钟内给予，给药后2 - 6小时进行手术。采用琼脂扩散法，浓度范围为0.05 - 0.6μg/g。采用电泳法发现强力霉素水平较高，这可能是由于骨结合能力降低所致。
