Collignon A, Chaumard C, Vallet-Collomb I, Delepine N
Service de Bactériologie, Hôpital Herold, Paris.
Pathol Biol (Paris). 1988 Jun;36(5 Pt 2):754-8.
We looked for C. difficile and its cytotoxin among children and adolescents treated with diverse kinds of cancer chemotherapy in an oncologic ward of a pediatric hospital. Most of them were also given multiple antibiotic treatments, susceptible of making C. difficile colonization easier due to the modification of the intestinal ecosystem. As the colonization may have an external origin, we also looked for C. difficile in the environment. 14 patients have been studied and we found cytotoxic strains in four of them and non cytotoxic ones in two. This paper discusses the influence of cancer chemotherapy and antibiotherapy on C. difficile colonization among those patients, and the role played by this bacteria and its toxin on the diarrhea cycle. The facts that several patients have been colonized together and that environmental samples showed up positive, lead us to suspect a nosocomial spread. To confirm this thesis, strains originating from patients and environments were compared.
我们在一家儿科医院的肿瘤病房中，对接受各种癌症化疗的儿童和青少年进行艰难梭菌及其细胞毒素的检测。他们中的大多数人还接受了多种抗生素治疗，由于肠道生态系统的改变，这些治疗易使艰难梭菌更容易定植。由于定植可能有外部来源，我们还对环境中的艰难梭菌进行了检测。我们研究了14名患者，其中4人发现了细胞毒性菌株，2人发现了非细胞毒性菌株。本文讨论了癌症化疗和抗生素治疗对这些患者中艰难梭菌定植的影响，以及这种细菌及其毒素在腹泻周期中所起的作用。有几名患者同时被定植，且环境样本呈阳性，这些事实让我们怀疑存在医院内传播。为证实这一论点，我们对来自患者和环境的菌株进行了比较。
