Department of Colorectal Surgery, The Third Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
First Clinical Medical College,Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.
J Cell Biochem. 2019 Apr;120(4):5687-5694. doi: 10.1002/jcb.27853. Epub 2018 Dec 11.
In this article, we aim to examine the novel effects of β-sitosterol on murine experimental colitis. β-Sitosterol significantly reduces the weight loss, colon length, and alleviated microscopic appearances of colitis induced by dextran sulfate sodium. This compound also decreases the levels of TNF-α, IL-6, and IL-1β in intestinal tissue of mice with experimental colitis in a concentration-dependent manner. β-Sitosterol treatment to intestinal epithelial cells significantly increases expression of antimicrobial peptides and reduces survival of intracellular Salmonella typhimurium. These results showed the multiple effects of β-sitosterol against pathogenic bacteria for a novel approach to the treatment of colonic inflammation.
在本文中，我们旨在研究β-谷甾醇对实验性结肠炎的新作用。β-谷甾醇可显著减轻葡聚糖硫酸钠诱导的结肠炎的体重减轻、结肠长度和缓解微观表现。该化合物还以浓度依赖的方式降低实验性结肠炎小鼠肠道组织中 TNF-α、IL-6 和 IL-1β 的水平。β-谷甾醇处理肠上皮细胞可显著增加抗菌肽的表达并降低细胞内鼠伤寒沙门氏菌的存活率。这些结果显示了β-谷甾醇对致病菌的多种作用，为治疗结肠炎症提供了一种新方法。
