Department of Psychology, Royal College of Surgeons in Ireland, Dublin, Ireland.
Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin, Ireland.
Acta Psychiatr Scand. 2019 Apr;139(4):304-310. doi: 10.1111/acps.12996. Epub 2019 Jan 4.
Exposure to prenatal stress is a ubiquitous and non-specific risk factor for adverse outcomes in adulthood. In this study, we examined associations between exposure to subjective maternal stress during pregnancy and subsequent diagnosis of psychiatric disorders in offspring.
This study used the Helsinki Longitudinal Temperament Cohort, a prospective birth cohort of individuals born between 1 July 1975 and 30 June 1976 in Helsinki, Finland. The sample for this study comprised 3626 infants whose mothers had completed health and well-being assessments during pregnancy which included a measure of self-reported stress. We ran logistic regressions to assess potential associations between prenatal stress and offspring psychiatric disorder in adulthood, identified through the Finnish Hospital Discharge Register.
Individuals whose mothers reported stress during pregnancy had significantly greater odds of developing a psychiatric disorder (OR = 1.41, 95% CI = 1.10-1.81) particularly a mood disorder (OR = 1.67, 95% CI = 1.10-2.54). These associations remained after adjusting for parental psychiatric history, and other prenatal factors.
Individuals exposed to prenatal stress had significantly increased risk of developing psychiatric disorders later in life. This finding highlights the importance of supporting the mental health and emotional well-being of women during pregnancy.
产前压力暴露是成年后不良后果的普遍且非特异性危险因素。本研究旨在探讨孕妇主观压力暴露与后代精神障碍诊断之间的关联。
本研究使用了赫尔辛基纵向气质队列，这是一个前瞻性出生队列，研究对象为 1975 年 7 月 1 日至 1976 年 6 月 30 日期间在芬兰赫尔辛基出生的个体。本研究的样本包括 3626 名婴儿，其母亲在怀孕期间完成了健康和幸福感评估，其中包括自我报告压力的测量。我们进行了逻辑回归分析，以评估产前压力与成年后代精神障碍之间的潜在关联，通过芬兰住院登记处确定。
报告怀孕期间有压力的母亲所生的子女患精神障碍（OR=1.41，95%CI=1.10-1.81）的可能性显著增加，特别是情绪障碍（OR=1.67，95%CI=1.10-2.54）。在调整了父母的精神病史和其他产前因素后，这些关联仍然存在。
暴露于产前压力的个体在以后的生活中患精神障碍的风险显著增加。这一发现强调了在怀孕期间支持女性的心理健康和情绪健康的重要性。
