Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi, India.
All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India.
Scand J Immunol. 2019 Mar;89(3):e12744. doi: 10.1111/sji.12744. Epub 2019 Jan 15.
Notch signalling is an evolutionarily conserved multifaceted pathway that controls diverse cellular processes. Its role in regulating development and tissue homeostasis is well established. Aberrant activation of the Notch pathway has been implicated in the initiation and progression of many types of cancers. However, although in some cancers Notch signalling acts as a tumour-promoter, in others it is reported to suppress tumour growth and progression. Accumulating evidence suggests the involvement of both the innate and adaptive immune system in the development of various tumours. Currently, extensive studies on investigating the effects of Notch signalling in tumour immune surveillance are being carried out. Interestingly, recent literature shows how the changing expression of Notch genes in different T cell subsets like CD4 and CD8 helps in controlling anti-tumour immune responses. In this review, we discuss in depth the roles of Notch signalling molecules and different immune cells in the context of the tumour microenvironment. We also outline how current knowledge can be exploited to develop novel therapies in order to control the propagation of cancer stem cells.
Notch 信号通路是一种进化上保守的多效性途径，它控制着多种细胞过程。其在调节发育和组织稳态中的作用已得到充分证实。 Notch 通路的异常激活与许多类型癌症的发生和进展有关。然而，尽管在一些癌症中 Notch 信号作为肿瘤促进剂发挥作用，但在其他癌症中，它被报道抑制肿瘤生长和进展。越来越多的证据表明，固有和适应性免疫系统都参与了各种肿瘤的发生。目前，正在进行广泛的研究，以调查 Notch 信号在肿瘤免疫监视中的作用。有趣的是，最近的文献表明， Notch 基因在不同 T 细胞亚群（如 CD4 和 CD8）中的表达变化如何有助于控制抗肿瘤免疫反应。在这篇综述中，我们深入讨论了 Notch 信号分子和不同免疫细胞在肿瘤微环境中的作用。我们还概述了如何利用现有知识开发新的治疗方法，以控制癌症干细胞的增殖。
