Department of Medicine, Rush University Medical Center, Chicago, IL, USA.
J Pathol. 2019 Apr;247(4):413-415. doi: 10.1002/path.5217. Epub 2019 Jan 25.
The role of dynamin in regulation of kidney filtration barrier is well documented. Dynamin binds to and produces filamentous actin, which is a key component of healthy podocyte foot processes (FPs). Destruction of dynamin, for example by cathepsin L, leads to loss of a functional actin network and uncoordinated membrane signaling, a situation that allows for effacement of FPs and proteinuria. Now, Khalil et al have examined the dynamin expression in kidneys of proteinuric animal models as well as in kidney patients and produced data that further clarifies the role of dynamin in glomerular and tubular proteinuria and may aid in pinpointing patients who are affected by loss of dynamin function and may benefit from appropriate therapeutic approaches. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
动力蛋白在调节肾脏滤过屏障中的作用已有充分的文献记载。动力蛋白与丝状肌动蛋白结合，并产生丝状肌动蛋白，这是健康足细胞足突（FPs）的关键组成部分。动力蛋白的破坏，例如通过组织蛋白酶 L，会导致功能性肌动蛋白网络的丧失和不协调的膜信号转导，这种情况允许 FPs 消失和蛋白尿。现在，Khalil 等人研究了蛋白尿动物模型以及肾病患者的肾脏中的动力蛋白表达，并提供了进一步阐明动力蛋白在肾小球和肾小管蛋白尿中的作用的数据，并可能有助于确定受动力蛋白功能丧失影响的患者，并可能受益于适当的治疗方法。版权所有 © 2018 大不列颠及爱尔兰病理学会。由 John Wiley & Sons，Ltd. 出版。
