Matsuki Akitomo
Nihon Ishigaku Zasshi. 2016 Dec;62(4):413-428.
Seishu Hanaoka's medicine is famed for its breast cancer surgery. Hanaoka, who,was motivated by Dokushoan Nagatomi's Man-yu zakki, published in 1771, had the idea to excise a breast cancer tumor and not to perform a breast amputation. Because he recognized that general anesthesia was indispensable for performing a surgical operation of the breast, he developed a general anesthetic and surmounted various difficulties: selection of an anesthetic method, anesthetic ingredients, determination of the opti- mal dosage, administration methods, indications and contra-indications, evaluation of the depth of anesthesia, facilitation of the smooth emergence from anesthesia, and postoperative care. I reviewed previous articles on these subjects and, using several unpublished manuscripts, provided new information on disseminated general anesthetics in Japan during the decade after the first general anesthesia for Kan Aiya in 1804.
华冈青州的医学以其乳腺癌手术而闻名。华冈青州受到1771年出版的长富直周的《万由杂记》的启发，萌生了切除乳腺癌肿瘤而非进行乳房切除术的想法。由于他认识到全身麻醉对于实施乳房手术是必不可少的，于是他研发了一种全身麻醉剂，并克服了各种困难：麻醉方法的选择、麻醉成分、最佳剂量的确定、给药方式、适应症和禁忌症、麻醉深度的评估、促进麻醉平稳苏醒以及术后护理。我查阅了以前关于这些主题的文章，并利用几份未发表的手稿，提供了1804年首次为间屋Kan实施全身麻醉后的十年间日本普及全身麻醉剂的新信息。
