Ogawa Yushi, Mimori Koshi
Nihon Rinsho. 2016 Nov;74(11):1807-1811.
MicroRNAs(miRNAs) are key regulators involved in various tumors. Recently, it has become clear that aberrant miRNA expression has a functional role in the initiation and progression of colorectal cancer (CRC). Distinct miRNA expression profiles have cancer- specific patterns and are associated with diagnosis, prognosis and therapeutic outcome in CRC. Many studies have shown that the miRNA play an important role in carcinogenesis, invasion and metastasis by regulating multiple target gene expressions and should be early detection biomarkers and therapeutic targets for CRC. Here we review the mechanisms and clinical uses of representative miRNAs in colorectal cancer.
微小RNA（miRNA）是参与各种肿瘤的关键调节因子。最近，很明显异常的miRNA表达在结直肠癌（CRC）的发生和发展中具有功能性作用。不同的miRNA表达谱具有癌症特异性模式，并与CRC的诊断、预后和治疗结果相关。许多研究表明，miRNA通过调节多个靶基因的表达在致癌作用、侵袭和转移中发挥重要作用，应该成为CRC的早期检测生物标志物和治疗靶点。在这里，我们综述了结直肠癌中代表性miRNA的作用机制及临床应用。
