Loo J C, Jordan N, McGilveray I J
Bureau of Drug Research, Health Protection Branch, Ottawa, Ontario, Canada.
Res Commun Chem Pathol Pharmacol. 1988 Aug;61(2):261-4.
A simplified, reverse-phase HPLC method utilizing a metal-free column was developed for the analysis of cyclosporin (CYA) in whole blood in humans. The average intra and inter assay variation at the low end of the therapeutic range are less than or equal to 4.5 and 8.8% respectively. The procedure was successfully applied to the measuring of CYA in whole blood collected from cardiac transplant patients over a one year period.
开发了一种利用无金属柱的简化反相高效液相色谱法，用于分析人体全血中的环孢素（CYA）。治疗范围低端的平均批内和批间变异分别小于或等于4.5%和8.8%。该方法成功应用于在一年时间内对心脏移植患者采集的全血中的CYA进行测定。
