Dang P, Gutmann L, Quentin C, Williamson R, Collatz E
Laboratoire de Microbiologie Médicale, Université de Paris VI, France.
Rev Infect Dis. 1988 Jul-Aug;10(4):899-904. doi: 10.1093/clinids/10.4.899.
Non-enzyme-dependent multiple-drug resistance occurs preferentially in some genera of Enterobacteriaceae, such as Serratia, Klebsiella, Enterobacter, and Salmonella. Susceptibility to beta-lactam antibiotics, aminoglycosides, quinolones, trimethoprim, and chloramphenicol may be affected in various combinations in different mutants. Proteins from the outer and inner membranes and lipopolysaccharides may be altered concomitantly. Although porin alterations have been observed in all resistant mutants studied, these modifications alone do not seem sufficient to explain the various cross-resistance phenotypes.
非酶依赖性多重耐药性优先发生于某些肠杆菌科属，如沙雷氏菌属、克雷伯氏菌属、肠杆菌属和沙门氏菌属。在不同突变体中，对β-内酰胺类抗生素、氨基糖苷类、喹诺酮类、甲氧苄啶和氯霉素的敏感性可能以各种组合受到影响。外膜、内膜和脂多糖的蛋白质可能会同时发生改变。尽管在所有研究的耐药突变体中都观察到孔蛋白的改变，但仅这些修饰似乎不足以解释各种交叉耐药表型。
