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乙二胺四乙酸（EDTA）和TOL-463对淋病奈瑟菌的体外活性

In vitro activity of EDTA and TOL-463 against Neisseria gonorrhoeae.

作者信息

Nash Evelyn E, Henning Tara C, Pham Cau D, Pettus Kevin, Sharpe Samera, Kersh Ellen N

机构信息

Division of Sexually Transmitted Disease Prevention, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, GA, USA.

Division of Sexually Transmitted Disease Prevention, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, GA, USA.

出版信息

Diagn Microbiol Infect Dis. 2019 Apr;93(4):369-371. doi: 10.1016/j.diagmicrobio.2018.10.021. Epub 2018 Nov 10.

DOI:10.1016/j.diagmicrobio.2018.10.021
PMID:30552033
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6519449/
Abstract

Neisseria gonorrhoeae quickly develops drug resistance. Time-kill curves revealed that EDTA and TOL-463 inhibit growth similar to penicillin, ciprofloxacin, and azithromycin. Furthermore, synergistic and additive antimicrobial interactions occurred when EDTA and TOL-463 were combined with penicillin or azithromycin, respectively, suggesting that further investigations into these unconventional antimicrobials may be advantageous.

摘要

淋病奈瑟菌迅速产生耐药性。时间杀菌曲线显示，乙二胺四乙酸（EDTA）和TOL - 463抑制生长的效果与青霉素、环丙沙星和阿奇霉素相似。此外，当EDTA和TOL - 463分别与青霉素或阿奇霉素联合使用时，会发生协同和相加的抗菌相互作用，这表明对这些非常规抗菌药物进行进一步研究可能是有益的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fcd/6519449/aafb4d335789/nihms-1028006-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fcd/6519449/aafb4d335789/nihms-1028006-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fcd/6519449/aafb4d335789/nihms-1028006-f0001.jpg

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