Klaassen C D
Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City 66103.
Toxicol Pathol. 1988;16(2):130-7. doi: 10.1177/019262338801600205.
Biliary excretion of xenobiotics is a complex process involving uptake into liver, intracellular sequestration and/or biotransformation, and transport into bile. A description of liver morphology is included to aid in the understanding of how chemical and physiological factors affect hepatic uptake and biliary excretion. Data will be presented with morphine and nalorphine that illustrate how efficient the intestinal and hepatobiliary system is in clearing drugs from the body. However, enterohepatic circulation can interfere with these processes.
外源性物质的胆汁排泄是一个复杂的过程，包括进入肝脏、细胞内隔离和/或生物转化，以及转运到胆汁中。文中包含肝脏形态的描述，以帮助理解化学和生理因素如何影响肝脏摄取和胆汁排泄。将给出吗啡和烯丙吗啡的数据，以说明肠道和肝胆系统从体内清除药物的效率。然而，肠肝循环会干扰这些过程。
