• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

相较于甲哌卡因和丙胺卡因,在门诊膝关节镜检查中使用氯普鲁卡因进行椎管内麻醉可更早出院并提高手术室效率。

Using chloroprocaine for spinal anaesthesia in outpatient knee-arthroscopy results in earlier discharge and improved operating room efficiency compared to mepivacaine and prilocaine.

机构信息

Department of Anaesthesiology and Surgical Intensive Care Medicine, University Medical Centre Mannheim, Ruprecht-Karls-University Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.

Department of Medical Statistics, University Medical Centre Mannheim, Ruprecht-Karls-University Heidelberg, Heinrich-Lanz-Zentrum, 68135, Mannheim, Germany.

出版信息

Knee Surg Sports Traumatol Arthrosc. 2019 Sep;27(9):3032-3040. doi: 10.1007/s00167-018-5327-2. Epub 2018 Dec 14.

DOI:10.1007/s00167-018-5327-2
PMID:30552467
Abstract

PURPOSE

Knee arthroscopies are regularly carried out in an outpatient setting. The purpose of this retrospective analysis was to investigate the impact of different local anaesthetics for spinal anaesthesia on operating room efficiency (perioperative process times) and postoperative recovery. This study aims to determine the optimal LA for SPA in patients undergoing knee arthroscopy at a day-surgery centre.

METHODS

Anaesthesia records of all patients undergoing knee arthroscopy under spinal anaesthesia from 2010 until 2017 were analysed. Patients were categorised as having received spinal anaesthesia with prilocaine, mepivacaine or chloroprocaine.

RESULTS

Three-hundred and nine patients were included. Postoperative recovery was significantly faster for chloroprocaine 1% compared with both other local anaesthetics regarding all stages of recovery until discharge. Perioperative processes and surgery time were significantly shorter when chloroprocaine was used. Early postoperative pain occurred more frequently and earlier after spinal anaesthesia with chloroprocaine. Nevertheless, pain intensity did not differ between groups.

CONCLUSION

Spinal anaesthesia provides reliable blocks for outpatient knee arthroscopy. Considerations on the choice of local anaesthetic for spinal anaesthesia must include not only the recovery profile, but also the impact on operating room efficiency. Due to a superior recovery profile, low incidences of adverse side effects and raised operating room efficiency, chloroprocaine is the recommendable local anaesthetic for spinal anaesthesia in patients undergoing knee arthroscopy in an ambulatory setting. Since the frequency of SPA in patients undergoing outpatient knee arthroscopy is rising yearly, the results of this study are of high clinical relevance. The use of chloroprocaine leads to improved recovery, optimized perioperative processes and consecutively to a raised OR efficiency.

LEVEL OF EVIDENCE

III.

摘要

目的

膝关节镜检查通常在门诊环境下进行。本回顾性分析的目的是研究不同局部麻醉药用于椎管内麻醉对手术室效率(围手术期时间)和术后恢复的影响。本研究旨在确定日间手术中心行膝关节镜检查患者行椎管内麻醉时的最佳局部麻醉药。

方法

分析了 2010 年至 2017 年间所有接受椎管内麻醉下膝关节镜检查的患者的麻醉记录。将患者分为接受普鲁卡因、甲哌卡因或氯普鲁卡因椎管内麻醉的患者。

结果

共纳入 309 例患者。与其他两种局部麻醉药相比,氯普鲁卡因 1%在所有恢复阶段直至出院时的术后恢复均明显更快。使用氯普鲁卡因时,围手术期过程和手术时间明显更短。氯普鲁卡因椎管内麻醉后早期发生的术后疼痛更频繁且更早。然而,各组之间的疼痛强度没有差异。

结论

椎管内麻醉可为门诊膝关节镜检查提供可靠的阻滞。在选择椎管内麻醉的局部麻醉药时,不仅要考虑恢复情况,还要考虑对手术室效率的影响。由于氯普鲁卡因具有更好的恢复情况、较低的不良反应发生率和更高的手术室效率,因此对于在日间手术环境下行膝关节镜检查的患者,氯普鲁卡因是椎管内麻醉的推荐局部麻醉药。由于每年接受门诊膝关节镜检查的 SPA 患者数量不断增加,因此本研究结果具有重要的临床意义。使用氯普鲁卡因可改善恢复情况、优化围手术期过程,并提高手术室效率。

证据水平

III 级。

相似文献

1
Using chloroprocaine for spinal anaesthesia in outpatient knee-arthroscopy results in earlier discharge and improved operating room efficiency compared to mepivacaine and prilocaine.相较于甲哌卡因和丙胺卡因,在门诊膝关节镜检查中使用氯普鲁卡因进行椎管内麻醉可更早出院并提高手术室效率。
Knee Surg Sports Traumatol Arthrosc. 2019 Sep;27(9):3032-3040. doi: 10.1007/s00167-018-5327-2. Epub 2018 Dec 14.
2
Retrospective analysis of mepivacaine, prilocaine and chloroprocaine for low-dose spinal anaesthesia in outpatient perianal procedures.回顾性分析甲哌卡因、丙胺卡因和氯普鲁卡因用于门诊肛周手术的低剂量脊髓麻醉。
Int J Colorectal Dis. 2018 Oct;33(10):1469-1477. doi: 10.1007/s00384-018-3085-8. Epub 2018 May 13.
3
Spinal anaesthesia with chloroprocaine 1% versus total intravenous anaesthesia for outpatient knee arthroscopy: A randomised controlled trial.氯普鲁卡因 1%腰麻与全凭静脉麻醉用于门诊膝关节镜检查:一项随机对照试验。
Eur J Anaesthesiol. 2018 Oct;35(10):774-781. doi: 10.1097/EJA.0000000000000794.
4
Comparison of 2-Chloroprocaine, Bupivacaine, and Lidocaine for Spinal Anesthesia in Patients Undergoing Knee Arthroscopy in an Outpatient Setting: A Double-Blind Randomized Controlled Trial.门诊膝关节镜检查患者中2-氯普鲁卡因、布比卡因和利多卡因用于脊髓麻醉的比较:一项双盲随机对照试验
Reg Anesth Pain Med. 2016 Sep-Oct;41(5):576-83. doi: 10.1097/AAP.0000000000000420.
5
Chloroprocaine 40 mg produces shorter spinal block than articaine 40 mg in day-case knee arthroscopy patients.氯普鲁卡因 40mg 用于日间膝关节镜检查患者时产生的脊髓阻滞短于 40mg 阿替卡因。
Acta Anaesthesiol Scand. 2013 Aug;57(7):911-9. doi: 10.1111/aas.12107. Epub 2013 Mar 25.
6
Plain articaine or prilocaine for spinal anaesthesia in day-case knee arthroscopy: a double-blind randomized trial.用于日间膝关节镜手术脊髓麻醉的普通阿替卡因或丙胺卡因:一项双盲随机试验。
Br J Anaesth. 2009 Feb;102(2):259-63. doi: 10.1093/bja/aen357. Epub 2008 Dec 25.
7
Chloroprocaine vs. articaine as spinal anaesthetics for day-case knee arthroscopy.氯普鲁卡因与阿替卡因用于日间膝关节镜检查的脊柱麻醉比较。
Acta Anaesthesiol Scand. 2011 Mar;55(3):273-81. doi: 10.1111/j.1399-6576.2010.02325.x. Epub 2010 Oct 7.
8
A comparison of spinal, epidural, and general anesthesia for outpatient knee arthroscopy.门诊膝关节镜检查中脊髓麻醉、硬膜外麻醉和全身麻醉的比较。
Anesth Analg. 2000 Oct;91(4):860-4. doi: 10.1097/00000539-200010000-00017.
9
Regional anaesthesia for outpatient knee arthroscopy: a randomized clinical comparison of two different anaesthetic techniques.门诊膝关节镜检查的区域麻醉:两种不同麻醉技术的随机临床比较。
Acta Anaesthesiol Scand. 2000 May;44(5):543-7. doi: 10.1034/j.1399-6576.2000.00509.x.
10
Spinal mepivacaine with fentanyl for outpatient knee arthroscopy surgery: a randomized controlled trial.门诊膝关节镜手术中应用吗啡复合甲哌卡因的脊髓麻醉:一项随机对照试验。
Can J Anaesth. 2010 Jan;57(1):32-8. doi: 10.1007/s12630-009-9207-6. Epub 2009 Oct 24.

引用本文的文献

1
Retrospective comparison of chloroprocaine and mepivacaine in spinal anesthesia for same-day discharge TKA.氯普鲁卡因与甲哌卡因用于当日出院全膝关节置换术脊髓麻醉的回顾性比较
Knee Surg Relat Res. 2025 Aug 7;37(1):33. doi: 10.1186/s43019-025-00283-4.
2
Spinal Anesthesia for Ambulatory Surgery Using Hyperbaric Prilocaine vs Hyperbaric Bupivacaine: A Prospective Study.使用高压布比卡因与高压丙胺卡因行门诊手术脊髓麻醉的前瞻性研究。
Cureus. 2025 Jan 30;17(1):e78246. doi: 10.7759/cureus.78246. eCollection 2025 Jan.
3
A randomised, non-inferiority study of chloroprocaine 2% and ropivacaine 0.75% in ultrasound-guided axillary block.

本文引用的文献

1
Incidence and related factors for intraoperative failed spinal anaesthesia for lower limb arthroplasty.下肢关节置换术中椎管内麻醉失败的发生率及相关因素。
Acta Anaesthesiol Scand. 2018 Aug;62(7):993-1000. doi: 10.1111/aas.13118. Epub 2018 Mar 26.
2
Spinal anaesthesia with chloroprocaine 1% versus total intravenous anaesthesia for outpatient knee arthroscopy: A randomised controlled trial.氯普鲁卡因 1%腰麻与全凭静脉麻醉用于门诊膝关节镜检查:一项随机对照试验。
Eur J Anaesthesiol. 2018 Oct;35(10):774-781. doi: 10.1097/EJA.0000000000000794.
3
Spinal anaesthesia in outpatient and conventional surgery: A point of view from experienced French anaesthetists.
一项氯普鲁卡因 2%和罗哌卡因 0.75%用于超声引导腋路阻滞的随机、非劣效性研究。
Sci Rep. 2021 May 11;11(1):10035. doi: 10.1038/s41598-021-89483-y.
4
Chloroprocaine Provides Safe, Effective, Short-Acting Spinal Anesthesia Ideal for Ambulatory Surgeries: A Retrospective Review.氯普鲁卡因提供安全、有效、短效的脊髓麻醉,是门诊手术的理想选择:一项回顾性研究。
HSS J. 2020 Dec;16(Suppl 2):280-284. doi: 10.1007/s11420-019-09713-y. Epub 2019 Aug 26.
5
Spinal Anesthesia Using Chloroprocaine is Safe, Effective, and Facilitates Earlier Discharge in Selected Fast-track Total Hip Arthroplasty.在特定的快速康复全髋关节置换术中,使用氯普鲁卡因进行脊髓麻醉是安全、有效的,且有助于早期出院。
Arthroplast Today. 2020 Jun 1;6(3):305-308. doi: 10.1016/j.artd.2020.04.007. eCollection 2020 Sep.
6
Impact of Chloroprocaine on the Eligibility for Hospital Discharge in Patients Requiring Ambulatory Surgery Under Spinal Anesthesia: An Observational Multicenter Prospective Study.氯普鲁卡因对椎管内麻醉下日间手术患者出院资格的影响:一项观察性多中心前瞻性研究。
Adv Ther. 2020 Jan;37(1):541-551. doi: 10.1007/s12325-019-01172-5. Epub 2019 Dec 11.
门诊和常规手术中的椎管内麻醉:法国麻醉师的观点。
Anaesth Crit Care Pain Med. 2018 Jun;37(3):239-244. doi: 10.1016/j.accpm.2016.12.002. Epub 2016 Dec 19.
4
Comparison of 2-Chloroprocaine, Bupivacaine, and Lidocaine for Spinal Anesthesia in Patients Undergoing Knee Arthroscopy in an Outpatient Setting: A Double-Blind Randomized Controlled Trial.门诊膝关节镜检查患者中2-氯普鲁卡因、布比卡因和利多卡因用于脊髓麻醉的比较:一项双盲随机对照试验
Reg Anesth Pain Med. 2016 Sep-Oct;41(5):576-83. doi: 10.1097/AAP.0000000000000420.
5
Short-acting spinal anesthesia in the ambulatory setting.门诊环境下的短效脊髓麻醉。
Curr Opin Anaesthesiol. 2014 Dec;27(6):597-604. doi: 10.1097/ACO.0000000000000126.
6
[Spinal anesthesia versus general anesthesia in the surgical treatment of inguinal hernia. Cost-effectiveness analysis].[脊髓麻醉与全身麻醉用于腹股沟疝手术治疗的成本效益分析]
Rev Esp Anestesiol Reanim. 2014 May;61(5):254-61. doi: 10.1016/j.redar.2013.11.016. Epub 2014 Feb 13.
7
Comparison of unilateral and bilateral spinal anesthesia with 2% hyperbaric prilocaine in day-case inguinal herniorrhaphy: a randomized controlled trial.2% 重比重丙胺卡因用于日间腹股沟疝修补术中单侧与双侧脊髓麻醉的比较:一项随机对照试验
Minerva Anestesiol. 2014 Jun;80(6):685-91. Epub 2013 Nov 13.
8
[Use of 2 % hyperbaric prilocaine for spinal anesthesia : sensitivity analysis in outpatient surgery].[2%高压布比卡因用于脊髓麻醉:门诊手术中的敏感性分析]
Anaesthesist. 2013 Apr;62(4):271-7. doi: 10.1007/s00101-013-2159-9. Epub 2013 Mar 29.
9
Modified PADSS (Post Anaesthetic Discharge Scoring System) for monitoring outpatients discharge.用于监测门诊患者出院情况的改良版麻醉后出院评分系统(PADSS)。
Ann Ital Chir. 2013 Nov-Dec;84(6):661-5.
10
Spinal anesthesia failure after local anesthetic injection into cerebrospinal fluid: a multicenter prospective analysis of its incidence and related risk factors in 1214 patients.局麻药注入脑脊液后脊髓麻醉失败:1214 例患者中发生率及相关危险因素的多中心前瞻性分析。
Reg Anesth Pain Med. 2011 Jul-Aug;36(4):322-6. doi: 10.1097/AAP.0b013e318217a68e.