C 反应蛋白/白蛋白比值对接受涉及喉切除术的侵襲性手術的下咽和喉癌患者的預后價值。
Prognostic value of C-reactive protein/albumin ratio for patients with hypopharyngeal and laryngeal cancer undergoing invasive surgery involving laryngectomy.
机构信息
Department of Otorhinolaryngology-Head and Neck Surgery, Dokkyo Medical University, Tochigi, Japan.
Department of Otolaryngology, The Jikei University School of Medicine, Tokyo, Japan.
出版信息
Head Neck. 2019 May;41(5):1342-1350. doi: 10.1002/hed.25565. Epub 2018 Dec 15.
BACKGROUND
The C-reactive protein/albumin (CRP/Alb) ratio has been recently established as a prognostic indicator in various cancer types. However, few reports regarding the prognostic value of the CRP/Alb ratio in head and neck cancer exist. This study aimed to investigate the significance of the CRP/Alb ratio in clinical outcomes after invasive surgery involving laryngectomy for hypopharyngeal and laryngeal cancer.
METHODS
We evaluated 56 patients who underwent total laryngectomy or total pharyngolaryngectomy between 2003 and 2012. Univariate and multivariate analyses were retrospectively performed to examine the prognostic value of the CRP/Alb ratio in these patients.
RESULTS
The optimal cutoff value of the CRP/Alb ratio was 0.32. Multivariate analysis showed that the CRP/Alb ratio was a significant and independent predictor of poor overall and disease-free survival.
CONCLUSION
The CRP/Alb ratio may be a novel and useful indicator for predicting postoperative outcomes in patients with hypopharyngeal and laryngeal cancer.
背景
C 反应蛋白/白蛋白（CRP/Alb）比值最近已被确立为各种癌症类型的预后指标。然而，关于 CRP/Alb 比值在头颈部癌症中的预后价值的报道很少。本研究旨在探讨 CRP/Alb 比值在接受下咽和喉癌根治性手术（全喉切除术或全咽-喉切除术）的患者临床结局中的意义。
方法
我们评估了 2003 年至 2012 年间接受全喉切除术或全咽-喉切除术的 56 例患者。对这些患者进行单因素和多因素分析，以检验 CRP/Alb 比值的预后价值。
结果
CRP/Alb 比值的最佳截断值为 0.32。多因素分析表明，CRP/Alb 比值是总生存和无病生存的显著且独立的预后预测因素。
结论
CRP/Alb 比值可能是预测下咽和喉癌患者术后结局的一种新的有用指标。
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