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尿 8-异前列腺素 F 作为稳定型冠状动脉疾病糖尿病患者罪犯斑块易损性的风险标志物。

Urinary 8-iso-prostaglandin F as a risk marker for the vulnerability of culprit plaque in diabetic patients with stable coronary artery disease.

机构信息

Center of Cardiology, Beijing An Zhen Hospital, Capital Medical University, No. 2 Anzhen Road, Chaoyang District, Beijing 100029, China.

Department of Thoracic Surgery, People Liberation Army General Hospital, Beijing 100853, China.

出版信息

Prostaglandins Leukot Essent Fatty Acids. 2019 Jan;140:11-17. doi: 10.1016/j.plefa.2018.11.008. Epub 2018 Nov 22.

DOI:10.1016/j.plefa.2018.11.008
PMID:30553398
Abstract

We evaluated the association of urinary excretion of 8-iso-prostaglandin F (8-iso-PGF) with the vulnerability of culprit lesions in 156 age- and sex-matched diabetic stable coronary artery disease (CAD) patients with or without thin-capped fibroatheroma (TCFA) identified by iMAP intravascular ultrasound. Fasting urinary 8-iso-PGF level was measured and corrected by creatinine clearance. Compared to non-TCFA group, patients with TCFA had higher urinary 8-iso-PGF levels [114.6 (71.1, 181.5) vs. 83.0 (63.2, 138.2) pmol/mmolCr, P = 0.012]. Urinary 8-iso-PGF level was positively correlated with percent necrotic volume of culprit lesion (r = 0.218, P = 0.006). High urinary 8-iso-PGF level (OR 2.941, P = 0.009) was independently associated with the presence of TCFA and displayed a significant value in predicting TCFA plaques in study patients. The current study indicated that urinary 8-iso-PGF may be an important surrogate marker for the vulnerability of culprit lesion in diabetic patients with CAD.

摘要

我们评估了 156 例年龄和性别匹配的糖尿病稳定型冠状动脉疾病（CAD）患者中，尿 8-异前列腺素 F（8-iso-PGF）排泄与罪犯病变易损性的相关性，这些患者通过 iMAP 血管内超声确定有无薄帽纤维粥样斑块（TCFA）。测定并通过肌酐清除率校正了空腹尿 8-iso-PGF 水平。与非 TCFA 组相比，TCFA 患者的尿 8-iso-PGF 水平更高[114.6（71.1，181.5）比 83.0（63.2，138.2）pmol/mmolCr，P=0.012]。尿 8-iso-PGF 水平与罪犯病变的坏死体积百分比呈正相关（r=0.218，P=0.006）。高尿 8-iso-PGF 水平（OR 2.941，P=0.009）与 TCFA 的存在独立相关，在研究患者中对 TCFA 斑块具有显著预测价值。本研究表明，尿 8-iso-PGF 可能是糖尿病 CAD 患者罪犯病变易损性的一个重要替代标志物。

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