妊娠糖尿病围产期孕妇血浆二肽基肽酶-4水平与认知功能的关联
Association between plasma dipeptidyl peptidase-4 levels and cognitive function in perinatal pregnant women with gestational diabetes mellitus.
作者信息
Sana Si-Ri-Gu-Leng, Li En-You, Deng Xi-Jin, Guo Lei
机构信息
Department of Anesthesiology, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China.
Department of Anesthesiology, the Second Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China.
出版信息
World J Clin Cases. 2021 Nov 26;9(33):10161-10171. doi: 10.12998/wjcc.v9.i33.10161.
BACKGROUND
Dipeptidyl peptidase-4 (DPP4) is associated with cognitive dysfunction in patients with type 2 diabetes.
AIM
To assess a possible relationship between serum DPP4 and cognitive function in perinatal pregnant women with gestational diabetes mellitus (GDM).
METHODS
The study subjects were divided into three groups: GDM group ( = 81), healthy pregnant (HP) group ( = 85), and control group ( = 51). The Montreal Cognitive Assessment (MoCA) was used to assess the cognitive status of each group. Venous blood samples were collected to measure blood lipids, glycated hemoglobin, and glucose levels. For each participant, a 3-mL blood sample was collected and centrifuged, and the serum was collected. Blood samples were stored at -80 ℃, and DPP4, interleukin-6 (IL-6), and 8-iso-prostaglandin F2α (8-iso-PGF2α), and brain-derived neurotrophic factor (BDNF) were detected using ELISA.
RESULTS
The MoCA scores in the GDM and HP groups were significantly different from those in the control group in terms of visuospatial/executive function and attention ( 0.05); however, the scores were not significantly different between the GDM and HP groups ( > 0.05). In terms of language, the GDM group had significantly different scores from those in the other two groups ( 0.05). In terms of memory, a significant difference was found between the HP and control groups ( < 0.05), as well as between the GDM and HP groups. The levels of DPP4, IL-6, and 8-iso-PGF2α in the GDM group were significantly higher than those in the HP and control groups ( < 0.05); however, the differences between these levels in the HP and control groups were not significant ( > 0.05). The level of BDNF in the GDM group was significantly lower than that in the HP and control groups ( < 0.05), although the difference in this level between the HP and control groups was not significant ( > 0.05).
CONCLUSION
Cognitive dysfunction in perinatal pregnant women with GDM mainly manifested as memory loss, which might be associated with elevated DPP4 levels.
背景
二肽基肽酶-4（DPP4）与2型糖尿病患者的认知功能障碍有关。
目的
评估妊娠期糖尿病（GDM）围产期孕妇血清DPP4与认知功能之间的可能关系。
方法
研究对象分为三组：GDM组（n = 81）、健康孕妇（HP）组（n = 85）和对照组（n = 51）。采用蒙特利尔认知评估量表（MoCA）评估各组的认知状态。采集静脉血样本以测量血脂、糖化血红蛋白和血糖水平。为每位参与者采集3 mL血样并离心，收集血清。血样保存在-80℃，采用酶联免疫吸附测定法（ELISA）检测DPP4、白细胞介素-6（IL-6）、8-异前列腺素F2α（8-iso-PGF2α）和脑源性神经营养因子（BDNF）。
结果
在视觉空间/执行功能和注意力方面，GDM组和HP组的MoCA评分与对照组相比有显著差异（P < 0.05）；然而，GDM组和HP组之间的评分无显著差异（P > 0.05）。在语言方面，GDM组的评分与其他两组有显著差异（P < 0.05）。在记忆方面，HP组和对照组之间以及GDM组和HP组之间均有显著差异（P < 0.05）。GDM组中DPP4、IL-6和8-iso-PGF2α的水平显著高于HP组和对照组（P < 0.05）；然而，HP组和对照组之间这些水平的差异不显著（P > 0.05）。GDM组中BDNF的水平显著低于HP组和对照组（P < 0.05），尽管HP组和对照组之间该水平的差异不显著（P > 0.05）。
结论
GDM围产期孕妇的认知功能障碍主要表现为记忆力减退，这可能与DPP4水平升高有关。
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