Department of Genetics & Cell Biology, Faculty of Health, Medicine and Life Sciences (FHML), Maastricht University, Maastricht, The Netherlands; Current affiliation: Leading-edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Daegu, Republic of Korea.
Department of Genetics & Cell Biology, Faculty of Health, Medicine and Life Sciences (FHML), Maastricht University, Maastricht, The Netherlands; Current affiliation: Department of Pathology, CARIM, Maastricht University Medical Center+ (MUMC+), Maastricht, the Netherlands.
Prostaglandins Leukot Essent Fatty Acids. 2019 Jan;140:51-56. doi: 10.1016/j.plefa.2018.11.016. Epub 2018 Nov 29.
The endocannabinoids anandamide (AEA) and 2-arachidonoylglyerol (2-AG) are endogenous lipid mediators that exert protective roles in pathophysiological conditions, including cardiovascular diseases. In this brief review, we provide a conceptual framework linking endocannabinoid signaling to the control of the cellular and molecular hallmarks, and categorize the key components of endocannabinoid signaling that may serve as targets for novel therapeutics. The emerging picture not only reinforces endocannabinoids as potent regulators of cellular metabolism but also reveals that endocannabinoid signaling is mechanistically more complex and diverse than originally thought.
内源性大麻素（AEA）和 2-花生四烯酸甘油（2-AG）是内源性脂质介质，在包括心血管疾病在内的病理生理条件下发挥保护作用。在这篇简短的综述中，我们提供了一个概念框架，将内源性大麻素信号与对细胞和分子特征的控制联系起来，并对可能作为新型治疗靶点的内源性大麻素信号的关键成分进行分类。这一新兴的图景不仅强化了内源性大麻素作为细胞代谢强有力调节剂的作用，而且还揭示了内源性大麻素信号比最初认为的更为复杂和多样化。
