Cannabis, cannabinoid receptors, and endocannabinoid system: yesterday, today, and tomorrow.
作者信息
Wu Jie
机构信息
Qingdao University Brain Science and Disease Institute, Qingdao, 266021, China.
St. Joseph's Hospital and Medical Center, Barrow Neurological Institute, Phoenix, AZ, USA.
出版信息
Acta Pharmacol Sin. 2019 Mar;40(3):297-299. doi: 10.1038/s41401-019-0210-3. Epub 2019 Jan 22.
Abstract
摘要
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Translational potential of allosteric modulators targeting the cannabinoid CB receptor.靶向大麻素 CB 受体的变构调节剂的翻译潜力。
Acta Pharmacol Sin. 2019 Mar;40(3):324-335. doi: 10.1038/s41401-018-0164-x. Epub 2018 Oct 17.
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Computational systems pharmacology analysis of cannabidiol: a combination of chemogenomics-knowledgebase network analysis and integrated in silico modeling and simulation.计算系统药理学分析大麻二酚：基于化学生物基因组学知识库网络分析及整合的计算模拟。
Acta Pharmacol Sin. 2019 Mar;40(3):374-386. doi: 10.1038/s41401-018-0071-1. Epub 2018 Sep 10.
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Heterogeneity of cannabinoid ligand-induced modulations in intracellular Ca signals of mouse pancreatic acinar cells in vitro.体外培养的小鼠胰腺腺泡细胞中大麻素配体诱导的细胞内 Ca 信号的异质性。
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Identification of novel mouse and rat CB1R isoforms and in silico modeling of human CB1R for peripheral cannabinoid therapeutics.鉴定新型小鼠和大鼠 CB1R 同工型，并对人 CB1R 进行计算机建模以用于外周大麻素治疗。
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Cannabidiol does not display drug abuse potential in mice behavior.大麻二酚在小鼠行为中不表现出滥用药物的潜力。
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Integrating endocannabinoid signaling in the regulation of anxiety and depression.整合内源性大麻素信号在焦虑和抑郁的调节中。
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Developmental and behavioral effects in neonatal and adult mice following prenatal activation of endocannabinoid receptors by capsaicin.辣椒素激活内源性大麻素受体对新生和成年小鼠发育和行为的影响。
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