Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, GA, USA.
Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, GA, USA.
Am J Emerg Med. 2019 Sep;37(9):1681-1685. doi: 10.1016/j.ajem.2018.12.007. Epub 2018 Dec 6.
Uncomplicated episodes of prolonged acute cough are usually viral and self-limited, but despite evidence and recommendations to the contrary, they are often treated with antibiotics.
Mixed cross-sectional and prospective observational study of adults 18 years or older presenting to two urgent care centers with a cough of 7 to 56 days as their chief complaint. Factors associated with cough duration and clinical decisions were analyzed by univariate and multivariate logistic regression.
Of the 125 enrolled patients, 118 (94%) received an antibiotic, 97 (78%) a cough suppressant, 87 (70%) a systemic corticosteroid, and 39 (31%) a chest X-ray (CXR). Longer duration of cough was associated with the presence of self-reported wheezing or noises (adjusted odds ratio 6.29, 95% CI 1.36-29.16) while the presence of both wheezing and crackles on a clinician chest exam was associated with shorter duration (aOR 0.03, 95% CI 0.00-0.27). A clinician was more likely to order a CXR in patients with dyspnea (aOR 3.01, 95% CI 1.21-7.49), less likely to prescribe a systemic corticosteroid in patients with crackles (aOR 0.27, 95% CI 0.09-0.82), and more likely to prescribe a cough suppressant to older patients (1.04 per additional year of age, 95% CI 1.01-1.07).
Systemic corticosteroids and cough suppressants are being prescribed at high rates in patients with uncomplicated acute cough in the urgent care setting. Additional studies to determine if similar rates are seen in other urgent care centers, or in other contemporary ambulatory settings are warranted.
单纯性迁延性急性咳嗽通常为病毒感染且具有自限性,但尽管有证据和建议与之相悖,此类咳嗽仍常被抗生素治疗。
本研究为混合性横断面和前瞻性观察性研究,纳入了在两家急诊就诊的 18 岁及以上的急性咳嗽(咳嗽持续 7 至 56 天)患者。采用单变量和多变量逻辑回归分析咳嗽持续时间和临床决策的相关因素。
125 名入组患者中,118 名(94%)接受了抗生素治疗,97 名(78%)使用了镇咳药,87 名(70%)接受了全身皮质激素治疗,39 名(31%)接受了胸部 X 线检查(CXR)。报告有自行感知的喘鸣或杂音与咳嗽持续时间较长相关(调整后的优势比 6.29,95%可信区间 1.36-29.16),而医生听诊时既闻及喘鸣又闻及爆裂音与咳嗽持续时间较短相关(比值比 0.03,95%可信区间 0.00-0.27)。有呼吸困难的患者更有可能接受 CXR 检查(比值比 3.01,95%可信区间 1.21-7.49),而有爆裂音的患者更不可能接受全身皮质激素治疗(比值比 0.27,95%可信区间 0.09-0.82),年龄较大的患者更有可能使用镇咳药(每增加 1 岁,比值比为 1.04,95%可信区间 1.01-1.07)。
在急诊就诊的单纯性急性咳嗽患者中,全身皮质激素和镇咳药的使用率较高。需要进一步研究以确定在其他急诊中心或其他当代门诊环境中是否存在类似的高使用率。