Department of Medical Biochemistry, Amsterdam UMC, University of Amsterdam, Academic Medical Center, Amsterdam Cardiovascular Sciences, Meibergdreef 9, room K1-115, 1105 AZ Amsterdam, The Netherlands.
Department of Medical Biochemistry, Amsterdam UMC, University of Amsterdam, Academic Medical Center, Amsterdam Cardiovascular Sciences, Meibergdreef 9, room K1-115, 1105 AZ Amsterdam, The Netherlands.
Trends Cardiovasc Med. 2019 Nov;29(8):429-437. doi: 10.1016/j.tcm.2018.11.015. Epub 2018 Dec 4.
Heart failure is characterized by the constant interplay between the underlying cardiac insult, degree of myocardial dysfunction and the activity of compensatory neurohormonal mechanisms. The sympathetic nervous system (SNS) and renin-angiotensin-aldosterone system (RAAS) become activated to maintain cardiac output; however, their chronic hyperactivity will eventually become deleterious. Several nuclear hormone receptors, including the mineralocorticoid receptor and estrogen receptor, are well-known to modulate cardiac disease. Recently, the subfamily of NR4A nuclear receptors i.e. Nur77, Nurr1 and NOR-1, are emerging as key players in cardiac stress responses, as well as pivotal regulators of neurohormonal mechanisms. In this review, we summarize current literature on NR4A nuclear receptors in the heart and in various components of the SNS, RAAS and immune system and discuss the functional implications for NR4As in cardiac function and disease.
心力衰竭的特征是潜在的心脏损伤、心肌功能障碍的程度和代偿性神经激素机制的活性之间的持续相互作用。交感神经系统（SNS）和肾素-血管紧张素-醛固酮系统（RAAS）被激活以维持心输出量；然而，它们的慢性过度活跃最终会造成损害。几种核激素受体，包括盐皮质激素受体和雌激素受体，已被证明可调节心脏疾病。最近，NR4A 核受体亚家族，即 Nur77、Nurr1 和 NOR-1，作为心脏应激反应的关键参与者以及神经激素机制的重要调节剂而出现。在这篇综述中，我们总结了关于 NR4A 核受体在心脏以及 SNS、RAAS 和免疫系统的各个组成部分中的现有文献，并讨论了 NR4A 在心脏功能和疾病中的功能意义。
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