Department of Life Sciences, Parul Institute of Applied Sciences, Parul University, Vadodara, Gujarat, 391760, India.
Bioinformatics Laboratory, Research & Development Cell, Parul University, Vadodara, Gujarat, 391760, India.
Sci Rep. 2024 Sep 27;14(1):22044. doi: 10.1038/s41598-024-69635-6.
The negative impact of SARS-CoV-2 virus infection on cardiovascular disease (CVD) patients is well established. This research article explores the cellular pathways involved in underlying heart diseases after infection. The systemic inflammatory response to SARS-CoV-2 infection likely exacerbates this increased cardiovascular risk; however, whether the virus directly infects cardiomyocytes remains unknown due to limited multi-omics data. While public transcriptome data exists for COVID-19 infection in different cell types (including cardiomyocytes), infection times vary between studies. We used available RNA-seq data from human heart tissue to delineate SARS-CoV-2 infection and heart failure aetiology specific gene expression signatures. A total of fifty-four samples from four studies were analysed. Our aim was to investigate specific transcriptome changes occurring in cardiac tissue with SARS-CoV-2 infection compared to non-infected controls. Our data establish that SARS-CoV-2 infects cardiomyocytes by the TNF-NF-κB pathway, potentially triggering acute cardiovascular complications and increasing the long-term cardiovascular risk in COVID-19 patients.
SARS-CoV-2 病毒感染对心血管疾病（CVD）患者的负面影响已得到充分证实。本研究文章探讨了感染后潜在心脏病的细胞途径。SARS-CoV-2 感染引起的全身炎症反应可能会加剧这种心血管风险增加；然而，由于多组学数据有限，病毒是否直接感染心肌细胞仍不清楚。虽然针对不同细胞类型（包括心肌细胞）的 COVID-19 感染存在公共转录组数据，但研究之间的感染时间不同。我们使用来自人类心脏组织的可用 RNA-seq 数据来描绘 SARS-CoV-2 感染和心力衰竭病因的特定基因表达特征。对来自四项研究的共 54 个样本进行了分析。我们的目的是研究与未感染对照相比，心肌组织中发生的特定转录组变化。我们的数据表明，SARS-CoV-2 通过 TNF-NF-κB 途径感染心肌细胞，可能引发急性心血管并发症，并增加 COVID-19 患者的长期心血管风险。
