Das B S, Satpathy S K, Mohanty D, Mohanty S, Mishra S K, Satapathy P C, Patnaik J K, Bose T K
Rourkela Steel Plant, Ispat General Hospital, Orissa, India.
Trans R Soc Trop Med Hyg. 1988;82(2):197-201. doi: 10.1016/0035-9203(88)90407-5.
The incidence of hypoglycaemia and the role of quinine in its causation was assessed in 46 patients with severe Plasmodium falciparum malaria. Plasma glucose and immunoreactive insulin were estimated before, during and after quinine therapy. In 5 patients the plasma glucose was in the hypoglycaemic range, the lowest value being 0.67 mmol/litre (12 mg/dl) in a pregnant patient. Most of the remaining patients showed a significant fall in plasma glucose (P less than 0.05), but not to the hypoglycaemic range, and an increase in plasma insulin after quinine (P less than 0.01). A good correlation was found between these changes (r = 0.79, P less than 0.01). Patients with severe P. falciparum malaria, particularly those on quinine therapy, should be watched carefully for developing hypoglycaemia.
对46例重症恶性疟原虫疟疾患者的低血糖发生率及其病因中奎宁的作用进行了评估。在奎宁治疗前、治疗期间和治疗后测定了血浆葡萄糖和免疫反应性胰岛素。5例患者的血浆葡萄糖处于低血糖范围，其中1例孕妇的最低值为0.67毫摩尔/升（12毫克/分升）。其余大多数患者的血浆葡萄糖显著下降（P<0.05），但未降至低血糖范围，且奎宁治疗后血浆胰岛素升高（P<0.01）。这些变化之间存在良好的相关性（r=0.79，P<0.01）。重症恶性疟原虫疟疾患者，尤其是接受奎宁治疗的患者，应密切观察是否发生低血糖。
