a Change Grow Live , London , UK.
b Centre for Mental Health and Safety , University of Manchester , Manchester , UK.
Clin Toxicol (Phila). 2019 May;57(5):368-371. doi: 10.1080/15563650.2018.1527927. Epub 2018 Dec 16.
To use a pilot of national fentanyl screening to establish the current prevalence of recent fentanyl use among treated users of illicit opioids in the English treatment system and inform the design of a full study.
Cross-sectional fentanyl metabolite urine screening in randomly-selected study sites, stratified to cover all nine geographical regions of England, supplemented with self-report subsequent to a positive fentanyl test.
468 adult (18 years of age and above) patients receiving treatment for opioid use disorder, screened December 2017 to May 2018.
The fentanyl-positive rate in patients receiving treatment for opioid use disorder in the English treatment system was 3% (15/468, 95% CI 1.8% to 5.2%) with a per-site range (for the 10 sites in 9 regions where fentanyl was detected) of between 2% (1/57) and 15% (4/27). Self-report data indicated that the majority of fentanyl-positives (12/15, 80%) was unaware of having purchased fentanyl.
Despite alerts already in place, patients receiving treatment for opioid use disorder, who were fentanyl-positive, were unwittingly purchasing and consuming fentanyl.
利用全国芬太尼筛查试点，了解英国治疗体系中接受非法阿片类药物治疗的患者近期使用芬太尼的现患率，为全面研究设计提供信息。
在随机选择的研究点进行横断面芬太尼代谢物尿液筛查，分层覆盖英格兰的所有九个地理区域，并在芬太尼检测呈阳性后进行自我报告。
468 名接受阿片类药物使用障碍治疗的成年（18 岁及以上）患者，于 2017 年 12 月至 2018 年 5 月接受筛查。
在英国治疗体系中接受阿片类药物使用障碍治疗的患者中，芬太尼阳性率为 3%（15/468，95%置信区间 1.8%至 5.2%），各检测点范围（在检测到芬太尼的 9 个地区的 10 个检测点）在 2%（1/57）至 15%（4/27）之间。自我报告数据表明，大多数芬太尼阳性者（12/15，80%）并不知道自己购买了芬太尼。
尽管已经发出警报，但接受阿片类药物使用障碍治疗且芬太尼检测呈阳性的患者在不知情的情况下购买并使用了芬太尼。
