Semjonov Aleksandr, Raath Jacobus P, Laubscher Liesel, Orro Toomas, Pfitzer Silke, Tiirats Toomas, Rogers Peter Stewart, Andrianov Vladimir
Chair of Clinical Veterinary Medicine, Institute of Veterinary Medicine and Animal Sciences, Estonian University of Life Sciences, Tartu, Estonia; Wildlife Pharmaceuticals South Africa (Pty) Ltd., White River, South Africa.
Wildlife Pharmaceuticals South Africa (Pty) Ltd., White River, South Africa; Wildlifevets.com Ngongoni Game Lodge, Karino, South Africa.
Vet Anaesth Analg. 2019 Jan;46(1):90-95. doi: 10.1016/j.vaa.2018.09.038. Epub 2018 Sep 22.
The butorphanol-azaperone-medetomidine fixed-dose combination (BAM, respectively, 30-12-12 mg mL) with subsequent antagonism by naltrexone-atipamezole was evaluated for reversible immobilization of captive cheetahs (Acinonyx jubatus).
Prospective, clinical trial.
Twelve cheetahs (six males and six females, weighing 37-57 kg) housed in enclosures, were immobilized at Hoedspruit Endangered Species Centre in the Republic of South Africa.
BAM volume dose rate was 0.009-0.014 mL kg (mean ± standard deviation 0.010 ± 0.001 mL kg). Total dose in all animals was 0.5 mL. The actual doses were as follows: butorphanol (0.29 ± 0.04 mg kg), azaperone (0.12 ± 0.01 mg kg) and medetomidine (0.12 ± 0.01 mg kg). Physiologic variables and quality of immobilization were recorded every 5 minutes beginning at 15-20 minutes after darting. Arterial blood samples were collected three times at 20, 30 and 40 minutes after darting from all animals for analysis of blood oxygenation and acid-base status.
The inductions were calm and smooth and mean induction time was 4.0 ± 1.1 minutes. Heart rate (50 ± 9 beats minute) and respiratory frequency (20 ± 3 breaths minute) were stable throughout immobilization. The recovery time after reversing with naltrexone and atipamezole was 9.1 ± 3.6 minutes.
and clinical relevance BAM proved to be a reliable and cardiovascular stable drug combination for immobilization of cheetahs.
评估布托啡诺-阿扎哌隆-美托咪定固定剂量组合（分别为30-12-12毫克/毫升）以及随后用纳曲酮-阿替美唑进行拮抗，用于圈养猎豹（猎豹属）的可逆性制动效果。
前瞻性临床试验。
12只猎豹（6只雄性和6只雌性，体重37-57千克）饲养在围栏中，在南非共和国的霍德斯普鲁特濒危物种中心被制动。
布托啡诺-阿扎哌隆-美托咪定的体积剂量率为0.009-0.014毫升/千克（平均值±标准差0.010±0.001毫升/千克）。所有动物的总剂量为0.5毫升。实际剂量如下：布托啡诺（0.29±0.04毫克/千克）、阿扎哌隆（0.12±0.01毫克/千克）和美托咪定（0.12±0.01毫克/千克）。从注射后15-20分钟开始，每隔5分钟记录生理变量和制动质量。在注射后20、30和40分钟从所有动物身上采集三次动脉血样本，用于分析血液氧合和酸碱状态。
诱导过程平静且顺利，平均诱导时间为4.0±1.1分钟。在整个制动过程中，心率（50±9次/分钟）和呼吸频率（20±3次/分钟）保持稳定。用纳曲酮和阿替美唑逆转后的恢复时间为9.1±3.6分钟。
布托啡诺-阿扎哌隆-美托咪定被证明是一种用于猎豹制动的可靠且心血管稳定的药物组合。
