血液类固醇与子宫内膜癌的预后和脂肪分布有关。
Blood steroids are associated with prognosis and fat distribution in endometrial cancer.
机构信息
Department of Gynaecology and Obstetrics, Haukeland University Hospital, Bergen, Norway; Centre for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen, Norway.
Mohn Medical Imaging and Visualization Centre, Department of Radiology, Haukeland University Hospital, Bergen, Norway; Section for Radiology, Department of Clinical Medicine, University of Bergen, Bergen, Norway.
出版信息
Gynecol Oncol. 2019 Jan;152(1):46-52. doi: 10.1016/j.ygyno.2018.10.024. Epub 2018 Oct 26.
BACKGROUND
Despite being a hormone dependent cancer, there is limited knowledge regarding the relation between level of steroids in blood and prognosis for endometrial cancer (EC) patients.
METHODS
In this study we investigated plasma levels of 19 steroids using liquid-chromatography tandem mass-spectrometry in 38 postmenopausal EC patients, 19 with long, and 19 with short survival. We explored if estradiol levels were associated with specific abdominal fat distribution patterns and if transcriptional alterations related to estradiol levels could be observed in tumor samples.
RESULTS
The plasma steroid levels for DHEA, DHEAS, progesterone, 21 OH progesterone and E1S were significantly increased (all p < 0.05) in patients with long survival compared to short. Estradiol levels were significantly positively correlated with visceral fat percentage (p = 0.035), and an increased expression of genes involved in estrogen related signaling was observed in tumors from patients with high estradiol levels in plasma.
CONCLUSION
Several of the identified plasma steroids represent promising biomarkers in EC patients. The association between increased estradiol levels and a high percentage of visceral fat indicates that visceral fat is a larger contributor to estradiol production compared to subcutaneous fat in this population.
背景
尽管子宫内膜癌（EC）是一种激素依赖性癌症，但关于血液中类固醇水平与 EC 患者预后之间的关系，人们知之甚少。
方法
本研究使用液相色谱-串联质谱法在 38 例绝经后 EC 患者中检测了 19 种类固醇的血浆水平，其中 19 例患者生存时间较长，19 例患者生存时间较短。我们探讨了雌二醇水平是否与特定的腹部脂肪分布模式有关，以及是否可以观察到与雌二醇水平相关的转录变化在肿瘤样本中。
结果
与生存时间较短的患者相比，生存时间较长的患者的血浆类固醇水平（DHEA、DHEAS、孕酮、21-OH 孕酮和 E1S）显著升高（均 p<0.05）。雌二醇水平与内脏脂肪百分比呈显著正相关（p=0.035），并且在血浆中雌二醇水平较高的患者的肿瘤中观察到与雌激素相关信号转导相关的基因表达增加。
结论
鉴定出的几种血浆类固醇是 EC 患者有前途的生物标志物。雌二醇水平升高与内脏脂肪百分比升高之间的关联表明，与该人群中的皮下脂肪相比，内脏脂肪是雌二醇产生的更大贡献者。
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