以EB病毒、长链非编码RNA和微小RNA为重点的鼻咽癌转移调控网络。
The regulatory network of nasopharyngeal carcinoma metastasis with a focus on EBV, lncRNAs and miRNAs.
作者信息
Zhao Chen-Xuan, Zhu Wei, Ba Zheng-Qing, Xu Hong-Juan, Liu Wei-Dong, Zhu Bin, Wang Lei, Song Yu-Jia, Yuan Shuai, Ren Cai-Ping
机构信息
The Key Laboratory of Carcinogenesis of The Chinese Ministry of Health and The Key Laboratory of Carcinogenesis and Cancer Invasion of The Chinese Ministry of Education, Xiangya Hospital, Central South University Changsha 410008, Hunan, P. R. China.
Cancer Research Institute, Collaborative Innovation Center for Cancer Medicine, School of Basic Medical Science, Central South University Changsha 410078, Hunan, P. R. China.
出版信息
Am J Cancer Res. 2018 Nov 1;8(11):2185-2209. eCollection 2018.
Metastasis of nasopharyngeal carcinoma (NPC) remains a main cause of death for NPC patients even though great advances have been made in therapeutic approaches. An in-depth study into the molecular mechanisms of NPC metastasis will help us combat NPC. Epstein-Barr virus (EBV) infection is an evident feature of nonkeratinizing NPC and is strongly associated with tumor metastasis. Recently, long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) have become a hot topic of research due to their epigenetic regulatory roles in NPC metastasis. The EBV products, lncRNAs and miRNAs can target each other and share several common signaling pathways, which form an interconnected, complex molecular regulatory network. In this review, we discuss the features of this regulatory network and summarize the molecular mechanisms of NPC metastasis, focusing on EBV, lncRNAs and miRNAs with updated knowledge.
尽管在治疗方法上已经取得了巨大进展，但鼻咽癌（NPC）转移仍然是NPC患者死亡的主要原因。深入研究NPC转移的分子机制将有助于我们对抗NPC。爱泼斯坦-巴尔病毒（EBV）感染是非角化性NPC的一个明显特征，并且与肿瘤转移密切相关。最近，长链非编码RNA（lncRNAs）和微小RNA（miRNAs）因其在NPC转移中的表观遗传调控作用而成为研究热点。EBV产物、lncRNAs和miRNAs可以相互靶向并共享几个共同的信号通路，形成一个相互连接的复杂分子调控网络。在这篇综述中，我们讨论了这个调控网络的特征，并总结了NPC转移的分子机制，重点关注EBV、lncRNAs和miRNAs的最新知识。
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